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Deep learning predicts DNA methylation regulatory variants in specific brain cell types and enhances fine mapping for brain disorders.

Science advances
DNA methylation (DNAm) is essential for brain development and function and potentially mediates the effects of genetic risk variants underlying brain disorders. We present INTERACT, a transformer-based deep learning model to predict regulatory varian...

Detection of focal cortical dysplasia: Development and multicentric evaluation of artificial intelligence models.

Epilepsia
OBJECTIVE: Focal cortical dysplasia (FCD) is a common cause of drug-resistant focal epilepsy but can be challenging to detect visually on magnetic resonance imaging. Three artificial intelligence models for automated FCD detection are publicly availa...

Using Machine Learning to Predict Weight Gain in Adults: an Observational Analysis From the All of Us Research Program.

The Journal of surgical research
INTRODUCTION: Obesity, defined as a body mass index ≥30 kg/m, is a major public health concern in the United States. Preventative approaches are essential, but they are limited by an inability to accurately predict individuals at highest risk of weig...

Virtual reality-assisted prediction of adult ADHD based on eye tracking, EEG, actigraphy and behavioral indices: a machine learning analysis of independent training and test samples.

Translational psychiatry
Given the heterogeneous nature of attention-deficit/hyperactivity disorder (ADHD) and the absence of established biomarkers, accurate diagnosis and effective treatment remain a challenge in clinical practice. This study investigates the predictive ut...

Prediction of prognosis in patients with cerebral contusions based on machine learning.

Scientific reports
Traumatic brain injury (TBI) is a global issue and a major cause of patient mortality, and cerebral contusions (CCs) is a common primary TBI. The haemorrhagic progression of a contusion (HPC) poses a significant risk to patients' lives, and effective...

Direct perception of affective valence from vision.

Nature communications
Subjective feelings are thought to arise from conceptual and bodily states. We examine whether the valence of feelings may also be decoded directly from objective ecological statistics of the visual environment. We train a visual valence (VV) machine...

Food for thought: a qualitative assessment of medical trainee and faculty perceptions of nutrition education.

BMC medical education
BACKGROUND: The American Society of Clinical Nutrition recommends 37 to 44 h of undergraduate medical nutrition education. The Total Health Curriculum at Geisinger Commonwealth School of Medicine (GCSOM) contains 14 h of objective-based nutritional i...

Utilising causal inference methods to estimate effects and strategise interventions in observational health data.

PloS one
Randomised controlled trials (RCTs) are the gold standard for evaluating health interventions but often face ethical and practical challenges. When RCTs are not feasible, large observational data sets emerge as a pivotal resource, though these data s...

Performance metrics outperform physiological indicators in robotic teleoperation workload assessment.

Scientific reports
Robotics holds the potential to streamline the execution of repetitive and dangerous tasks, which are difficult or impossible for a human operator. However, in complex scenarios, such as nuclear waste management or disaster response, full automation ...