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Zebrafish

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Effect of abiotic and biotic stress factors analysis using machine learning methods in zebrafish.

Comparative biochemistry and physiology. Part D, Genomics & proteomics
In order to understand the mechanisms underlying stress responses, meta-analysis of transcriptome is made to identify differentially expressed genes (DEGs) and their biological, molecular and cellular mechanisms in response to stressors. The present ...

Fuzzy-based propagation of prior knowledge to improve large-scale image analysis pipelines.

PloS one
Many automatically analyzable scientific questions are well-posed and a variety of information about expected outcomes is available a priori. Although often neglected, this prior knowledge can be systematically exploited to make automated analysis op...

A Support Vector Machine based method to distinguish long non-coding RNAs from protein coding transcripts.

BMC genomics
BACKGROUND: In recent years, a rapidly increasing number of RNA transcripts has been generated by thousands of sequencing projects around the world, creating enormous volumes of transcript data to be analyzed. An important problem to be addressed whe...

Gene Ontology-Based Analysis of Zebrafish Omics Data Using the Web Tool Comparative Gene Ontology.

Zebrafish
Gene Ontology (GO) analysis is a powerful tool in systems biology, which uses a defined nomenclature to annotate genes/proteins within three categories: "Molecular Function," "Biological Process," and "Cellular Component." GO analysis can assist in r...

A new cyclic lipopeptide isolated from Bacillus amyloliquefaciens HAB-2 and safety evaluation.

Pesticide biochemistry and physiology
Bacillus is the most widely studied biocontrol agent and has been extensively used in the development of biopesticides and fungicides. In this study, a new cyclic lipopeptide was isolated from Bacillus amyloliquefaciens HAB-2 by column chromatography...

The allelopathic effect and safety evaluation of 3,4-Dihydroxybenzalacetone on Microcystis aeruginosa.

Pesticide biochemistry and physiology
Harmful algal blooms (HABs) has been a serious problem in recent years, because of large quantities of cyanobacterial in eutrophic water. We studied the effects of 3,4-Dihydroxybenzalacetone (DBL) and other four compounds (vanillic acid, ferulic acid...

A versatile and low-cost open source pipetting robot for automation of toxicological and ecotoxicological bioassays.

PloS one
In the past decades, bioassays and whole-organism bioassay have become important tools not only in compliance testing of industrial chemicals and plant protection products, but also in the monitoring of environmental quality. With few exceptions, suc...

Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.

Journal of neuroscience methods
BACKGROUND: Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment. Zebrafish larvae show great potential to serve as an animal model of epilepsy in drug discovery. Thanks to their high fecundity and relatively...

Anticancer and anti-inflammatory activities of girinimbine isolated from .

Drug design, development and therapy
Therapy that directly targets apoptosis and/or inflammation could be highly effective for the treatment of cancer. is an edible herb that has been traditionally used for cancer treatment as well as inflammation. Here, we describe that girinimbine, a...

Anticancer activity of biologically synthesized silver and gold nanoparticles on mouse myoblast cancer cells and their toxicity against embryonic zebrafish.

Materials science & engineering. C, Materials for biological applications
The aim of this study was to evaluate the anticancer activity of bioinspired silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) against mouse myoblast cancer cells (CC). Both AgNPs and AuNPs were biologically synthesized using Spinacia olera...