We propose a patient-specific ("personalized") approach for tailoring the injected activities to individual patients in order to achieve dose reduction in SPECT-myocardial perfusion imaging (MPI). First, we develop a strategy to determine the minimum...
Positron emission tomography (PET) has been substantially used recently. To minimize the potential health risk caused by the tracer radiation inherent to PET scans, it is of great interest to synthesize the high-quality PET image from the low-dose on...
Various types of atherosclerotic plaque and varying grades of stenosis could lead to different management of patients with a coronary artery disease. Therefore, it is crucial to detect and classify the type of coronary artery plaque, as well as to de...
Hyperspectral imaging (HSI) of tissue samples in the mid-infrared (mid-IR) range provides spectro-chemical and tissue structure information at sub-cellular spatial resolution. Disease states can be directly assessed by analyzing the mid-IR spectra of...
Mild cognitive impairment (MCI) detection is important, such that appropriate interventions can be imposed to delay or prevent its progression to severe stages, including Alzheimer's disease (AD). Brain connectivity network inferred from the function...
Segmentation in 3-D scans is playing an increasingly important role in current clinical practice supporting diagnosis, tissue quantification, or treatment planning. The current 3-D approaches based on convolutional neural networks usually suffer from...
Medical datasets are often highly imbalanced with over-representation of prevalent conditions and poor representation of rare medical conditions. Due to privacy concerns, it is challenging to aggregate large datasets between health care institutions....
The findings of splenomegaly, abnormal enlargement of the spleen, is a non-invasive clinical biomarker for liver and spleen diseases. Automated segmentation methods are essential to efficiently quantify splenomegaly from clinically acquired abdominal...
Quasi-static elasticity imaging techniques rely on model-based mathematical inverse methods to estimate mechanical parameters from force-displacement measurements. These techniques introduce simplifying assumptions that preclude exploration of unknow...
Histopathological examination is today's gold standard for cancer diagnosis. However, this task is time consuming and prone to errors as it requires a detailed visual inspection and interpretation of a pathologist. Digital pathology aims at alleviati...
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