AIMC Topic: Adult

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.

Antiviral therapy
BACKGROUND: This Phase I, two-part, first-in-human study assessed safety/tolerability and pharmacokinetics/pharmacodynamics of single-ascending doses (SAD) and multiple doses (MD) of the oral toll-like receptor-7 agonist, JNJ-64794964 (JNJ-4964) in h...

Effect of pedestrian physique differences on head injury prediction in car-to-pedestrian accidents using deep learning.

Traffic injury prevention
OBJECTIVE: The aim of this study is to identify the effects of pedestrian physique differences on head injury prediction in car-to-pedestrian accidents via deep learning.

Phenotype Discovery and Geographic Disparities of Late-Stage Breast Cancer Diagnosis across U.S. Counties: A Machine Learning Approach.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
BACKGROUND: Disparities in the stage at diagnosis for breast cancer have been independently associated with various contextual characteristics. Understanding which combinations of these characteristics indicate highest risk, and where they are locate...

Artificial intelligence strategy integrating morphologic and architectural biomarkers provides robust diagnostic accuracy for disease progression in chronic lymphocytic leukemia.

The Journal of pathology
Artificial intelligence-based tools designed to assist in the diagnosis of lymphoid neoplasms remain limited. The development of such tools can add value as a diagnostic aid in the evaluation of tissue samples involved by lymphoma. A common diagnosti...

Diagnosis of Pneumonia by Cough Sounds Analyzed with Statistical Features and AI.

Sensors (Basel, Switzerland)
Pneumonia is a serious disease often accompanied by complications, sometimes leading to death. Unfortunately, diagnosis of pneumonia is frequently delayed until physical and radiologic examinations are performed. Diagnosing pneumonia with cough sound...

Brain oscillatory correlates of visuomotor adaptive learning.

NeuroImage
Sensorimotor adaptation involves the recalibration of the mapping between motor command and sensory feedback in response to movement errors. Although adaptation operates within individual movements on a trial-to-trial basis, it can also undergo learn...

Predictive modeling for 14-day unplanned hospital readmission risk by using machine learning algorithms.

BMC medical informatics and decision making
BACKGROUND: Early unplanned hospital readmissions are associated with increased harm to patients, increased medical costs, and negative hospital reputation. With the identification of at-risk patients, a crucial step toward improving care, appropriat...

Machine learning prediction of cognition from functional connectivity: Are feature weights reliable?

NeuroImage
Cognitive performance can be predicted from an individual's functional brain connectivity with modest accuracy using machine learning approaches. As yet, however, predictive models have arguably yielded limited insight into the neurobiological proces...

Exploring a new paradigm for the fetal anomaly ultrasound scan: Artificial intelligence in real time.

Prenatal diagnosis
OBJECTIVE: Advances in artificial intelligence (AI) have demonstrated potential to improve medical diagnosis. We piloted the end-to-end automation of the mid-trimester screening ultrasound scan using AI-enabled tools.

Can artificial intelligence replace ultrasound as a complementary tool to mammogram for the diagnosis of the breast cancer?

The British journal of radiology
OBJECTIVE: To study the impact of artificial intelligence (AI) on the performance of mammogram with regard to the classification of the detected breast lesions in correlation to ultrasound-aided mammograms.