BACKGROUND AND OBJECTIVES: Over half of all deaths after traumatic brain injury (TBI) follow the decision to withdraw life-sustaining therapy (WLST). Despite recent improvements in TBI mortality, rates of WLST have remained unchanged, potentially ref...
BACKGROUND: Cardiovascular disease remains the predominant cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Traditional risk models are limited in predictive accuracy. Pericoronary adipose tissue (PCAT), a novel i...
OBJECTIVE: The relationship between depression and obstructive sleep apnea (OSA) remains controversial. Therefore, this study aims to explore their association and utilize machine learning models to predict OSA among individuals with depression withi...
BACKGROUND: Small intestinal neuroendocrine neoplasms (SI-NENs), a subgroup of neuroendocrine tumors originating from neuroendocrine cells in the small intestine, present significant therapeutic challenges, and their relationship with ferroptosis-a r...
INTRODUCTION: Stroke is the second leading cause of death and disability creating a huge economic burden annually. Robot-assisted training (RT) is a promising therapy in stroke rehabilitation, but for the elderly, traditional 'reaching objects'" task...
BACKGROUND: Drug-drug interactions (DDIs) are a major concern, especially for older adults taking multiple medications. Although Health Canada and the US Food and Drug Administration (FDA) use population-based studies to identify adverse drug events,...
BACKGROUND: Machine learning (ML) has shown great potential in recognizing complex disease patterns and supporting clinical decision-making. Diabetic foot ulcers (DFUs) represent a significant multifactorial medical problem with high incidence and se...
BACKGROUND: Offline reinforcement learning (RL) has been increasingly applied to clinical decision-making problems. However, due to the lack of a standardized pipeline, prior work often relied on strategies that may lead to overfitted policies and in...
Archives of orthopaedic and trauma surgery
Oct 10, 2025
AIMS: The aim of this retrospective study was the evaluation of the patient-reported and radiological outcome of intravenous Iloprost therapy in the treatment of spontaneous osteonecrosis of the knee (SONK).
BACKGROUND: Controlling delayed cerebral ischemia (DCI) is crucial for improving the prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH). This study aimed to identify prognostic factors in patients with aSAH in Japan.
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