Transcription factors (TFs) can affect gene expression by binding to certain specific DNA sequences. This binding process of TFs may be modulated by DNA methylation. A subset of TFs that serve as methylation readers preferentially binds to certain me...
Molecular representation learning is pivotal in predicting molecular properties and advancing drug design. Traditional methodologies, which predominantly rely on homogeneous graph encoding, are limited by their inability to integrate external knowled...
With a burgeoning number of artificial intelligence (AI) applications in various fields, biomolecular science has also given a big welcome to advanced AI techniques in recent years. In this broad field, scoring a protein-ligand binding structure to o...
PURPOSE: Artificial intelligence (AI) tools could improve clinical decision making or exacerbate inequities because of bias. African American (AA) men reportedly have a worse prognosis for prostate cancer (PCa) and are underrepresented in the develop...
Technology and health care : official journal of the European Society for Engineering and Medicine
May 1, 2025
BackgroundWith the advancement of Artificial Intelligence (AI), clinical engineering has witnessed transformative opportunities, enabling predictive maintenance of medical devices, optimization of healthcare workflows, and personalized patient care. ...
Small molecules have been playing a crucial role in drug discovery; however, some exhibit nonspecific inhibitory effects during hit screening due to the formation of colloidal aggregators. Such false positives often lead to significant research costs...
Alzheimer's & dementia : the journal of the Alzheimer's Association
May 1, 2025
INTRODUCTION: Identifying individuals with dementia is crucial for prevalence estimation and service planning, but reliable, scalable methods are lacking. We developed novel set algorithms using both structured and unstructured electronic health reco...
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
May 1, 2025
OBJECTIVE: To outline immune-cell infiltration and identify diagnostic genes for atherosclerosis (AS) to better understand the potential molecular processes involved in AS development.
Structural variants (SVs) in microbial genomes play a critical role in phenotypic changes, environmental adaptation, and species evolution, with deletion variations particularly closely linked to phenotypic traits. Therefore, accurate and comprehensi...
Cancer imaging : the official publication of the International Cancer Imaging Society
May 1, 2025
BACKGROUND: As body mass index (BMI) increases, the quality of 2-deoxy-2-[fluorine-18]fluoro-D-glucose (F-FDG) positron emission tomography (PET) images reconstructed with ordered subset expectation maximization (OSEM) declines, negatively impacting ...
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