AIMC Topic: Alzheimer Disease
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Developing multifactorial dementia prediction models using clinical variables from cohorts in the US and Australia.
Translational psychiatry
Jan 21, 2025
Existing dementia prediction models using non-neuroimaging clinical measures have been limited in their ability to identify disease. This study used machine learning to re-examine the diagnostic potential of clinical measures for dementia. Data was s...
Sulfonic acid functionalized β-amyloid peptide aggregation inhibitors and antioxidant agents for the treatment of Alzheimer's disease: Combining machine learning, computational, in vitro and in vivo approaches.
International journal of biological macromolecules
Jan 20, 2025
Alzheimer's disease (AD) is characterized as a neurodegenerative disorder that is caused by plaque formation by accumulating β-amyloid (Aβ), leading to neurocognitive function and impaired mental development. Thus, targeting Aβ represents a promising...
Adapting to evolving MRI data: A transfer learning approach for Alzheimer's disease prediction.
NeuroImage
Jan 16, 2025
Integrating 3D magnetic resonance imaging (MRI) with machine learning has shown promising results in healthcare, especially in detecting Alzheimer's Disease (AD). However, changes in MRI technologies and acquisition protocols often yield limited data...
Screening of Aβ and phosphorylated tau status in the cerebrospinal fluid through machine learning analysis of portable electroencephalography data.
Scientific reports
Jan 15, 2025
Diagnosing Alzheimer's disease (AD) through pathological markers is typically costly and invasive. This study aims to find a noninvasive, cost-effective method using portable electroencephalography (EEG) to detect changes in AD-related biomarkers in ...
DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer's disease.
Scientific reports
Jan 15, 2025
Alzheimer's Disease (AD) significantly aggravates human dignity and quality of life. While newly approved amyloid immunotherapy has been reported, effective AD drugs remain to be identified. Here, we propose a novel AI-driven drug-repurposing method,...
Drug repurposing using artificial intelligence, molecular docking, and hybrid approaches: A comprehensive review in general diseases vs Alzheimer's disease.
Computer methods and programs in biomedicine
Jan 13, 2025
BACKGROUND: Alzheimer's disease (AD), the most prevalent form of dementia, remains enigmatic in its origins despite the widely accepted "amyloid hypothesis," which implicates amyloid-beta peptide aggregates in its pathogenesis and progression. Despit...
DML-MFCM: A multimodal fine-grained classification model based on deep metric learning for Alzheimer's disease diagnosis.
Journal of X-ray science and technology
Jan 13, 2025
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder. There are no drugs and methods for the treatment of AD, but early intervention can delay the deterioration of the disease. Therefore, the early diagnosis of AD and mild cognitive i...
Clinical validation of artificial intelligence-based single-subject morphometry without normative reference database.
Journal of Alzheimer's disease : JAD
Jan 12, 2025
BACKGROUND: Single-subject voxel-based morphometry (VBM) is a powerful technique for reader-independent detection of brain atrophy in structural magnetic resonance imaging (MRI) to support the (differential) diagnosis and staging of neurodegenerative...
GraphkmerDTA: integrating local sequence patterns and topological information for drug-target binding affinity prediction and applications in multi-target anti-Alzheimer's drug discovery.
Molecular diversity
Jan 10, 2025
Identifying drug-target binding affinity (DTA) plays a critical role in early-stage drug discovery. Despite the availability of various existing methods, there are still two limitations. Firstly, sequence-based methods often extract features from fix...
Predicting cognitive decline from neuropsychiatric symptoms and Alzheimer's disease biomarkers: A machine learning approach to a population-based data.
Journal of Alzheimer's disease : JAD
Jan 10, 2025
BACKGROUND: The aim of this study was to examine the potential added value of including neuropsychiatric symptoms (NPS) in machine learning (ML) models, along with demographic features and Alzheimer's disease (AD) biomarkers, to predict decline or no...
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