BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder that significantly impacts health care worldwide, particularly among the elderly population. The accurate classification of AD stages is essential for slowing disease progression an...
BackgroundMost common forms of dementia, including Alzheimer's disease, are associated with alterations in spoken language.ObjectiveThis study explores the potential of a speech-based machine learning (ML) approach in estimating cognitive impairment,...
International journal of molecular sciences
40004143
The development of BACE-1 (β-site amyloid precursor protein cleaving enzyme 1) inhibitors is a crucial focus in exploring early treatments for Alzheimer's disease (AD). Recently, graph neural networks (GNNs) have demonstrated significant advantages i...
International journal of molecular sciences
40004081
Approximately 50% of Alzheimer's disease (AD) patients develop psychotic symptoms, leading to a subtype known as psychosis in AD (AD + P), which is associated with accelerated cognitive decline compared to AD without psychosis. Currently, no FDA-appr...
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
40000185
Alzheimer's disease (AD) classification models usually segment the entire brain image into voxel blocks and assign them labels consistent with the entire image, but not every voxel block is closely related to the disease. To this end, an AD auxiliary...
Proceedings of the National Academy of Sciences of the United States of America
39993207
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since bi...
Alzheimer's disease (AD) is a progressive neurological condition characterized by cognitive decline, memory loss, and aberrant behaviour. It affects millions of people globally and is one of the main causes of dementia. The neurodegenerative conditio...
IEEE journal of biomedical and health informatics
40030424
Recent advancements in the classification of Alzheimer's disease have leveraged the automatic feature generation capability of convolutional neural networks (CNNs) using neuroimaging biomarkers. However, most of the existing CNN-based methods often d...
Amyloid- positron emission tomography can reflect the Amyloid- protein deposition in the brain and thus serves as one of the golden standards for Alzheimer's disease (AD) diagnosis. However, its practical cost and high radioactivity hinder its applic...
IEEE journal of biomedical and health informatics
40030727
The prevalence of Alzheimer's disease (AD) is rising annually, imposing a severe burden on patients and society. Therefore, assisted AD assessment is crucial. The decline in language function and the cognitive impairment it reflects are key external ...