Journal of chemical information and modeling
Mar 14, 2025
Ischemic stroke's complex pathophysiology demands therapeutic approaches targeting multiple pathways simultaneously, yet current treatments remain limited. We developed an innovative drug discovery pipeline combining a deep learning approach with exp...
Native ion mobility-mass spectrometry combined with collision-induced unfolding (CIU) is a powerful analytical method for protein characterization, offering insights into structural stability and enabling the differentiation of analytes with similar ...
Ecotoxicology and environmental safety
Mar 14, 2025
BACKGROUND: Within the past two decades, high-profile cases of melamine (MA) exposure have raised significant toxicological concerns, particularly regarding food adulteration. While widely used as a fundamental organic chemical intermediate in variou...
Critical reviews in oncology/hematology
Mar 13, 2025
The convergence of artificial intelligence (AI) and nanomedicine has revolutionized the design of smart multifunctional nanocarriers (SMNs) for drug and gene delivery, offering unprecedented precision, efficiency, and personalization in therapeutic a...
To date, the effect of cryopreservation on microcracks in the dental enamel remains unclear. These enamel microcracks are very thin, at the limit of visibility and their segmentation is beyond the capabilities of traditional image analysis. The objec...
Advanced imaging techniques, like magnetic resonance imaging (MRI), have revolutionised cardiovascular disease diagnosis and monitoring in humans and animal models. Real-time (RT) MRI, which can capture a single slice during each consecutive heartbea...
Advanced materials (Deerfield Beach, Fla.)
Mar 13, 2025
Micro/Nanorobots(MNRs)integrated with phototherapy represent an emerging approach to cancer treatment and hold significant potential for addressing bacterial infections, neurological disorders, cardiovascular diseases, and related conditions. By leve...
Computational drug design is a rapidly evolving field, especially the latest breakthroughs in generative artificial intelligence (GenAI) to create new compounds. However, the potential of GenAI to address the challenges in designing central nervous s...
Recent advancements in deep learning have significantly enhanced the segmentation of high-resolution microcomputed tomography (µCT) bone scans. In this paper, we present the dual-branch attention-based hybrid network (DBAHNet), a deep learning archit...
Effective fisheries management is the key to achieve sustainable fisheries globally, while accurate monitoring of fishing vessels is essential to improve the effectiveness of management measures. Self-reported information on vessel types is often lim...
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