AIMC Topic: Animals

Clear Filters Showing 2871 to 2880 of 8866 articles

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning.

Frontiers in immunology
BACKGROUND: Ischemic stroke (IS), caused by blood and oxygen deprivation due to cerebral thrombosis, has links to activated and aggregated platelets. Discovering platelet-related biomarkers, developing diagnostic models, and screening antiplatelet dr...

Automated Measurement of Ovary Development in Atlantic Salmon Using Deep Learning.

Ultrasound in medicine & biology
OBJECTIVE: Salmon breeding companies control the egg stripping period through environmental change, which triggers the need to identify the state of maturation. Ultrasound imaging of the salmon ovary is a proven non-invasive tool for this purpose; ho...

Integrative analysis of potential diagnostic markers and therapeutic targets for glomerulus-associated diabetic nephropathy based on cellular senescence.

Frontiers in immunology
INTRODUCTION: Diabetic nephropathy (DN), distinguished by detrimental changes in the renal glomeruli, is regarded as the leading cause of death from end-stage renal disease among diabetics. Cellular senescence plays a paramount role, profoundly affec...

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing organ-on-chip, omics, immune cell phenotyping and modeling to identify new therapeutics.

Frontiers in cellular and infection microbiology
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can develop from bacterial (gram negative or g...

A facile approach to preparing personalized cancer vaccines using iron-based metal organic framework.

Frontiers in immunology
BACKGROUND: Considering the diversity of tumors, it is of great significance to develop a simple, effective, and low-cost method to prepare personalized cancer vaccines.

Visible detection of chilled beef freshness using a paper-based colourimetric sensor array combining with deep learning algorithms.

Food chemistry
This study developed an innovative approach that combines a colourimetric sensor array (CSA) composed of twelve pH-response dyes with advanced algorithms, aiming to detect amine gases and assess the freshness of chilled beef. With the assistance of m...

Pain-free oral delivery of biologic drugs using intestinal peristalsis-actuated microneedle robots.

Science advances
Biologic drugs hold immense promise for medical treatments, but their oral delivery remains a daunting challenge due to the harsh digestive environment and restricted gastrointestinal absorption. Here, inspired by the porcupinefish's ability to infla...

Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation.

Nature cell biology
In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear whether this spatial variation, called zonation, is governed by a well-defined gene regulato...

Detection and prediction of pathogenic microorganisms in aquaculture (Zhejiang Province, China).

Environmental science and pollution research international
The detection and prediction of pathogenic microorganisms play a crucial role in the sustainable development of the aquaculture industry. Currently, researchers mainly focus on the prediction of water quality parameters such as dissolved oxygen for e...

DL-SPhos: Prediction of serine phosphorylation sites using transformer language model.

Computers in biology and medicine
Serine phosphorylation plays a pivotal role in the pathogenesis of various cellular processes and diseases. Roughly 81% of human diseases have links to phosphorylation, and an overwhelming 86.4% of protein phosphorylation takes place at serine residu...