AIMC Topic: Animals
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Transcriptomic analysis reveals novel targets in benign schwannoma using machine learning.
Neuroscience
Jun 21, 2025
BACKGROUND & OBJECTIVE: This study aimed to identify key immune-related biomarkers of benign schwannoma through machine learning-assisted transcriptomic and single-cell analyses, and to construct a predictive model for disease evaluation.
Accelerating vaccine development: Plug-and-play platforms for emerging infectious diseases.
Virus research
Jun 21, 2025
Emerging pathogens underscore an urgent need for rapidly developed vaccines to minimize mortality and societal disruption. Traditional vaccine development requires time spans of years, making it ill-suited to fast evolving viruses that can overwhelm ...
Three-dimensional U-Net with transfer learning improves automated whole brain delineation from MRI brain scans of rats, mice, and monkeys.
Computers in biology and medicine
Jun 20, 2025
BACKGROUND: Automated whole-brain delineation (WBD) techniques often struggle to generalize across pre-clinical studies due to variations in animal models, magnetic resonance imaging (MRI) scanners, and tissue contrasts. We developed a 3D U-Net neura...
Lineage-specific regulatory evolution: insights from massively parallel reporter assays.
Current opinion in genetics & development
Jun 20, 2025
Lineage-specific genetic variants play a key role in evolutionary divergence, particularly through changes in cis-regulatory elements that fine-tune gene expression. Massively parallel reporter assays (MPRAs) provide a powerful approach to characteri...
Advances in vaccine adjuvant development and future perspectives.
Drug delivery
Jun 19, 2025
Use of highly purified antigens to improve vaccine safety has led to reduced immunogenicity and efficacy, resulting in the need for adjuvants to increase and/or modulate the immunogenicity of the vaccine. Despite the need for potent and safe vaccine ...
Enhanced hermit crabs detection using super-resolution reconstruction and improved YOLOv8 on UAV-captured imagery.
Marine environmental research
Jun 19, 2025
Hermit crabs are vital to coastal ecosystems, serving as environmental health indicators and contributing to seed dispersal, debris cleanup, and soil disturbance. Traditional hermit crabs survey methods, like quadrat sampling, are labor-intensive and...
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy.
Pharmacological research
Jun 19, 2025
Galectin-3 (Gal-3) has emerged as a critical regulator of neuroinflammation and a promising therapeutic target for Alzheimer's disease (AD). Nevertheless, the development of brain-penetrant small-molecule Gal-3 inhibitors poses a significant challeng...
Sex determination in German Mast geese (Anser anser) with 3D modeling pelvimetry examination.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
Jun 19, 2025
BACKGROUND: The avian pelvis is known to differ in shape between males and females due to the need for females to lay eggs, with egg shape correlating to pelvic shape. Geese breeding is done as an alternative to the poultry sector in our country for ...
Bio-inspired swarm of underwater robots: a review.
Bioinspiration & biomimetics
Jun 19, 2025
With the in-depth integration of research across multiple disciplines, such as biomimetics, robotics, and sensing technology, significant advancements have been made in swarm robotics technology, which has been applied in areas including drone swarms...
Self-assembling peptide hydrogels: design, mechanisms, characterization, and biomedical applications.
Soft matter
Jun 19, 2025
Self-assembled peptide hydrogels have emerged as a research frontier in biomedical engineering due to their exceptional water-retention capacity and spatiotemporal drug release kinetics. Researchers can fabricate biomaterials with customizable struct...
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