AIMC Topic: Animals

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Crossing the blood-brain barrier: advances in dendrimer-based nanocarriers for central nervous system delivery.

Nanoscale
Dendrimer-based nanocarriers are emerging as transformative platforms to overcome the challenge of crossing the blood-brain barrier (BBB) in the treatment and diagnosis of central nervous system (CNS) disorders. Their highly branched, monodisperse ar...

Lactic acid bacteria as promising dietary-derived bioadsorbents for foodborne contaminants: Mechanism, application advances and future perspectives.

Food chemistry
Foodborne contaminants, such as mycotoxins and microplastics, pose significant threats to human health due to their high toxicity and persistence in the food chain, thus necessitate effective mitigation strategies. Lactic acid bacteria (LAB), charact...

NoAC: an automatic builder for knowledge bases and query interfaces on genomes of non-model organisms.

Journal of molecular biology
The cost of sequencing a genome has become affordable for many research groups. However, with the growing number of sequenced genomes from non-model organisms, manually building functional genome annotation knowledge databases for each species is no ...

Integrative transcriptomic and genomic insights into diabetic kidney disease: evidence from multi-omics analysis and experimental validation.

Renal failure
Diabetic kidney disease (DKD) remains a critical challenge in diabetes management, necessitating a deep understanding of its molecular underpinnings for better diagnosis and treatment strategies. This study was conducted to identify and validate nove...

Ocular implants and inserts: revolutionizing drug delivery in ophthalmology.

International journal of pharmaceutics
The ophthalmic route for drug administration remains a significant constraint in ophthalmology due to the unique anatomy and several protective barriers in the eyes, which limit absorption and therapeutic efficacy. Conventionally, drugs are delivered...

Zhilining formula alleviates ulcerative colitis by restricting STAT3 activation and subsequent Th17 cell differentiation.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease with rising prevalence and limited therapies. Zhilining Formula (ZLN), a Traditional Chinese Medicine (TCM), shows clinical efficacy in UC, yet its core material b...

Optimizing selective breeding of livestock and forage crops to reduce the environmental impacts of grass-based dairy production by combining life cycle assessment and machine learning.

The Science of the total environment
Global demand for ruminant milk-based products is increasing, contributing to increases in associated environmental impacts. Yet, most efforts to reduce the total environmental impact of dairy production are based on livestock breeding and manipulati...

Utilizing data science to assess native Indian freshwater fish taxa and their conservation status.

The Science of the total environment
India ranks ninth globally in freshwater fish diversity but lacks updated checklists and data-driven fish diversity and conservation assessments, which are essential for better informed decision-making on conservation and species discovery efforts. T...

Unlocking flow-habitat relationships in mountain rivers of Epirus, Greece using object detection and hydrodynamic simulation.

The Science of the total environment
Human activities impact aquatic ecosystems by altering abiotic and biotic factors, which in turn affect habitat structure and biodiversity. Environmental flows, or the necessary water flow levels to sustain ecosystems, influence fish habitats, with f...

Deep Learning-Enabled Unbiased Precision Toxicity Assessment of Zebrafish Organ Development.

Environmental science & technology
Precise assessment of toxicological effects remains a key bottleneck in biomedical and environmental health assessments. Traditional toxicology relies on macroscopic end points and manual image analysis, which limit sensitivity to structural damage a...