Neural networks : the official journal of the International Neural Network Society
Aug 18, 2018
Plasticity is one of the most important properties of the nervous system, which enables animals to adjust their behavior to the ever-changing external environment. Changes in synaptic efficacy between neurons constitute one of the major mechanisms of...
BACKGROUND: Dendritic spines are structural correlates of excitatory synapses in the brain. Their density and structure are shaped by experience, pointing to their role in memory encoding. Dendritic spine imaging, followed by manual analysis, is a pr...
Gene ontology (GO) provides a representation of terms and categories used to describe genes and their molecular functions, cellular components and biological processes. GO has been the standard for describing the functions of specific genes in differ...
BACKGROUND: During slow-wave sleep the electroencephalographic (EEG) and local field potential (LFP) recordings reveal the presence of large amplitude slow waves. Systematic extraction of individual slow waves is not trivial.
Lab organisms are valuable in part because of large-scale experiments like screens, but performing such experiments over long time periods by hand is arduous and error-prone. Organism-handling robots could revolutionize large-scale experiments in the...
IEEE/ACM transactions on computational biology and bioinformatics
Aug 15, 2018
It is well known that essential proteins play an extremely important role in controlling cellular activities in living organisms. Identifying essential proteins from protein protein interaction (PPI) networks is conducive to the understanding of cell...
Combinations of new antidepressants like duloxetine and second-generation antipsychotics like quetiapine are used in clinical treatment of major depressive disorder, as well as in forensic toxicology scenarios. The drug-drug interaction (DDI) between...
AIMS: Alzheimer's disease (AD) is one of the leading causes of death in elderly people. Its pathogenesis is greatly associated with the abnormality of immune system. However, only a few immune-relevant AD drug target genes have been discovered up to ...
We introduce a model-based image reconstruction framework with a convolution neural network (CNN)-based regularization prior. The proposed formulation provides a systematic approach for deriving deep architectures for inverse problems with the arbitr...
Cell-penetrating peptides (CPPs) facilitate the transport of pharmacologically active molecules, such as plasmid DNA, short interfering RNA, nanoparticles, and small peptides. The accurate identification of new and unique CPPs is the initial step to ...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.