Recent advances in theoretical biology suggest that key definitions of basal cognition and sentient behavior may arise as emergent properties of in vitro cell cultures and neuronal networks. Such neuronal networks reorganize activity to demonstrate s...
Phenotypic data are critical for understanding biological mechanisms and consequences of genomic variation, and are pivotal for clinical use cases such as disease diagnostics and treatment development. For over a century, vast quantities of phenotype...
Economic losses in cattle farms are frequently associated with failed pregnancies. Some studies found that the transcriptomic profiles of blood and endometrial tissues in cattle with varying pregnancy outcomes display discrepancies even before artifi...
Spatial transcriptomics (ST) technology provides gene expression profiles with spatial context, offering critical insights into cellular interactions and tissue architecture. A core task in ST is spatial domain identification, which involves detectin...
The blood brain barrier (BBB) is an endothelial-derived structure which restricts the movement of certain molecules between the general somatic circulatory system to the central nervous system (CNS). While the BBB maintains homeostasis by regulating ...
The Journal of the Acoustical Society of America
Mar 1, 2025
Whales generate vocalizations which may, deliberately or not, encode caller identity cues. In this study, we analyze calls produced by Bryde's whales and recorded by ocean-bottom arrays of hydrophones deployed close to the Costa Rica Rift in the Pana...
Journal of cellular and molecular medicine
Mar 1, 2025
Using machine learning approaches, we developed and validated a novel prognostic model for oesophageal squamous cell carcinoma (ESCC) based on glycolipid metabolism-related genes. Through integrated analysis of TCGA and GEO datasets, we established a...
BACKGROUND: Trophoblast cell surface antigen 2 (TROP2) is a promising target for various cancers, including breast cancer. The development of noninvasive techniques for assessing TROP2 expression in tumors holds considerable importance. This study ai...
The void spot assay has gained popularity as a way of assessing functional bladder voiding parameters in mice, but analyzing the size and distribution of urine spot patterns on filter paper with software remains problematic due to inter-laboratory di...
A successful drug needs to combine several properties including high potency and good pharmacokinetic (PK) properties to sustain efficacious plasma concentration over time. To estimate required doses for preclinical animal efficacy models or for the ...
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