AIMC Topic: Animals

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Neuronal and therapeutic perspectives on empathic pain: A rational insight.

Neuropharmacology Mar 11, 2025
Empathy is the capacity to experience and understand the feelings of others, thereby playing a key role in a person's mental well-being essentially by promoting kindness and a sense of belongingness to the group. However, too much empathy may result ...
Animals Pain Pain Perception Empathy Humans Brain Pain Management
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Therapeutic potential of Da Cheng Qi Decoction and its ingredients in regulating ferroptosis via the NOX2-GPX4 signaling pathway to alleviate and predict severe acute pancreatitis.

Cellular signalling Mar 11, 2025
OBJECTIVE: This study aimed to elucidate the protective effects of Da Cheng Qi Decoction (DCQD) on severe acute pancreatitis (SAP) by targeting ferroptosis in pancreatic acinar cells and to establish a predictive signature and nomogram for acute panc...
Animals Male Mice Humans Female Drugs, Chinese Herbal Pancreatitis NADPH Oxidase 2 Mice, Inbred C57BL Ferroptosis Signal Transduction
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Leveraging machine learning for drug repurposing in rheumatoid arthritis.

Drug discovery today Mar 11, 2025
Rheumatoid arthritis (RA) presents a significant challenge in clinical management because of the dearth of effective drugs despite advances in understanding its mechanisms. Drug repurposing has emerged as a promising strategy to address this gap, off...
Drug Repositioning Animals Humans Antirheumatic Agents Drug Discovery Machine Learning Arthritis, Rheumatoid
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Special issue European Journal of Physiology: Artificial intelligence in the field of physiology and medicine.

Pflugers Archiv : European journal of physiology Mar 11, 2025
This special issue presents a collection of reviews on the recent advancements and applications of artificial intelligence (AI) in medicine and physiology. The topics covered include digital histopathology, generative AI, explainable AI (XAI), and et...
Humans Artificial Intelligence Physiology Precision Medicine Animals
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SVLearn: a dual-reference machine learning approach enables accurate cross-species genotyping of structural variants.

Nature communications Mar 11, 2025
Structural variations (SVs) are diverse forms of genetic alterations and drive a wide range of human diseases. Accurately genotyping SVs, particularly occurring at repetitive genomic regions, from short-read sequencing data remains challenging. Here,...
Genotype Alleles Machine Learning Sheep Genome, Human Cattle Humans Genotyping Techniques Genomic Structural Variation Animals Genomics
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Unraveling the power of NAP-CNB's machine learning-enhanced tumor neoantigen prediction.

eLife Mar 11, 2025
In this study, we present a proof-of-concept classical vaccination experiment that validates the in silico identification of tumor neoantigens (TNAs) using a machine learning-based platform called NAP-CNB. Unlike other TNA predictors, NAP-CNB leverag...
Cancer Vaccines Antigens, Neoplasm Vaccination Neoplasms Humans Female Mice Machine Learning Animals Immunotherapy
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Living material-derived intelligent micro/nanorobots.

Biomaterials science Mar 11, 2025
Living materials, which include various types of cells, organelles, and biological components from animals, plants, and microorganisms, have become central to recent investigations in micro and nanorobotics. Living material-derived intelligent micro/...
Animals Robotics Nanotechnology Humans Drug Delivery Systems Biomimetic Materials
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Innovative construction and application of bile duct organoids: Unraveling the complexity of bile duct diseases and potential therapeutic strategies.

Cancer letters Mar 10, 2025
The biliary system is crucial for liver function, regulating bile production, secretion, and transport. Dysfunctions within this system can lead to various diseases, such as cholangiopathies and biliary fibrosis, which may progress from benign to mal...
Animals Regenerative Medicine Bile Ducts Humans Precision Medicine Organoids Tissue Engineering Bile Duct Diseases
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Genomic selection in pig breeding: comparative analysis of machine learning algorithms.

Genetics, selection, evolution : GSE Mar 10, 2025
BACKGROUND: The effectiveness of genomic prediction (GP) significantly influences breeding progress, and employing SNP markers to predict phenotypic values is a pivotal aspect of pig breeding. Machine learning (ML) methods are usually used to predict...
Breeding Selection, Genetic Animals Swine Phenotype Polymorphism, Single Nucleotide Models, Genetic Genomics Machine Learning Algorithms
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Rapid Blood Clot Removal via Remote Delamination and Magnetization of Clot Debris.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Mar 8, 2025
Micro/nano-scale robotic devices are emerging as a cutting-edge approach for precision intravascular therapies, offering the potential for highly targeted drug delivery. While employing micro/nanorobotics for stroke treatment is a promising strategy ...
Thrombolytic Therapy Blood Coagulation Thrombosis Thrombectomy Stroke Humans Animals Robotics
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