The lipophilic nature of 2-methylisoborneol (2-MIB), a prevalent off-flavor compound in aquatic systems, raises concerns about its bioaccumulation potential and metabolic interference in fish. Most studies have focused on removing this compound from ...
Understanding the complex three-dimensional structure of cells is crucial across many disciplines in biology and especially in neuroscience. Here, we introduce a set of models including a 3D transformer (SwinUNetR) and a novel 3D self-supervised lear...
Colloids and surfaces. B, Biointerfaces
Jun 23, 2025
High-entropy nanozymes (HENs) have emerged as a revolutionary class of bio-inspired catalysts that integrate multi-enzyme mimetic activities with environmental responsiveness, creating transformative opportunities for next-generation biosensing techn...
ETHNOPHARMACOLOGICAL RELEVANCE: Mulberry leaves (Morus alba L.) are used in traditional Chinese medicine to clear the lungs and dispel wind-heat. Despite their common use, chemical reference substance rely solely on rutin, which may not reflect their...
BACKGROUND: Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas...
Signal transduction and targeted therapy
Jun 23, 2025
Traumatic brain injury (TBI) is a major public health concern associated with an increased risk of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and chronic traumatic encephalopathy, yet the underlying molec...
Aquatic toxicology (Amsterdam, Netherlands)
Jun 22, 2025
The Danube flows through various European regions, exposing its aquatic ecosystem to multiple stressors, including dams, canalization, and agricultural activities. Fertilizers, manures, pesticides, animal husbandry activities, irrigation practices, d...
Emulsifiers maintain the stability of emulsions, and milk protein-formed emulsions are unstable. Hence, efficient ways to screen food-derived compounds need to be identified. This study combined molecular descriptors with machine learning algorithms ...
Ecotoxicology and environmental safety
Jun 21, 2025
This study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between t...
BACKGROUND & OBJECTIVE: This study aimed to identify key immune-related biomarkers of benign schwannoma through machine learning-assisted transcriptomic and single-cell analyses, and to construct a predictive model for disease evaluation.
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