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Antitubercular Agents

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Ethambutol-induced optic neuropathy in renal disorder: a clinico-electrophysiological study.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
OBJECTIVE: To report the spectrum of ethambutol induced optic neuropathy in a group of renal patients with tuberculosis and the role of visual evoked response (VER) in evaluating this disorder.

Automatic diagnostics of tuberculosis using convolutional neural networks analysis of MODS digital images.

PloS one
Tuberculosis is an infectious disease that causes ill health and death in millions of people each year worldwide. Timely diagnosis and treatment is key to full patient recovery. The Microscopic Observed Drug Susceptibility (MODS) is a test to diagnos...

iATP: A Sequence Based Method for Identifying Anti-tubercular Peptides.

Medicinal chemistry (Shariqah (United Arab Emirates))
BACKGROUND: Tuberculosis is one of the biggest threats to human health. Recent studies have demonstrated that anti-tubercular peptides are promising candidates for the discovery of new anti-tubercular drugs. Since experimental methods are still labor...

A machine learning-based framework for Predicting Treatment Failure in tuberculosis: A case study of six countries.

Tuberculosis (Edinburgh, Scotland)
Tuberculosis is ranked as the 2nd deadliest disease in the world and is responsible for ten million deaths in 2017. Treatment failure is one of a main reason behind these deaths. Reasons of treatment failure are still unknown and the death rate due t...

Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.

Scientific reports
Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have highlighted that these mutations reduce p...

An explainable machine learning platform for pyrazinamide resistance prediction and genetic feature identification of Mycobacterium tuberculosis.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Tuberculosis is the leading cause of death from a single infectious agent. The emergence of antimicrobial resistant Mycobacterium tuberculosis strains makes the problem more severe. Pyrazinamide (PZA) is an important component for short-co...