AIMC Topic: Antiviral Agents
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Ritonavir-boosted paritaprevir, ombitasvir plus ribavirin could improve eGFR in patients with renal impairment and HCV: an Egyptian cohort.
Expert review of gastroenterology & hepatology
Nov 13, 2018
BACKGROUND: The present study aimed at evaluation of changes in estimated glomerular filtration rate (eGFR) among chronic Hepatitis C virus (HCV) patients with chronic kidney disease (CKD) Stages 3-5 who were treated with 12 weeks of ritonavir-booste...
Female
Anilides
Aged
Carbamates
Young Adult
Lactams, Macrocyclic
Humans
Adult
Macrocyclic Compounds
Prospective Studies
Male
Ribavirin
Genotype
Hepacivirus
Sustained Virologic Response
Cyclopropanes
Middle Aged
Kidney
Proline
Renal Dialysis
Recovery of Function
Renal Insufficiency, Chronic
Drug Therapy, Combination
Viral Load
Egypt
Hepatitis C, Chronic
Treatment Outcome
Time Factors
Sulfonamides
Valine
Glomerular Filtration Rate
Antiviral Agents
[Hepatitis B and renal failure: prevalence and associated factors in National University Hospital Center of Cotonou].
The Pan African medical journal
Oct 17, 2018
INTRODUCTION: the association between the kidneys and hepatitis B is complex. This study aims to determine the prevalence and factors associated with renal disease in people living with hepatitis B virus (PLHBV) in Cotonou.
Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data.
PloS one
Jul 26, 2018
Chemogenomic approaches involving highly annotated compound sets and cell based high throughput screening are emerging as a means to identify novel drug targets. We have previously screened a collection of highly characterized kinase inhibitors (Khan...
Predictive factors of spontaneous CMV DNAemia clearance in kidney transplantation.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Dec 29, 2017
UNLABELLED: Cytomegalovirus (CMV) infection occurs frequently after solid organ transplantation. Therapeutic strategies, in particular when to start a curative treatment, has not yet been defined. The purpose of this study was to assess predictive fa...
Long-term incidence and predictors of hepatitis B surface antigen loss after discontinuing nucleoside analogues in noncirrhotic chronic hepatitis B patients.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Dec 26, 2017
OBJECTIVE: To investigate the long-term incidence and predictors for hepatitis B surface antigen (HBsAg) loss after nucleoside analogue therapy.
Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid.
Journal of the Chinese Medical Association : JCMA
Dec 26, 2017
BACKGROUND: The pandemic influenza A (H1N1) virus has spread worldwide and infected a large proportion of the human population. Discovery of new and effective drugs for the treatment of influenza is a crucial issue for the global medical community. A...
Antiviral activity of aconite alkaloids from Debx.
Natural product research
Dec 22, 2017
Four diterpenoid alkaloids, namely, () hypaconitine, ) songorine, () mesaconitine and () aconitine, were isolated from the ethanol root extract of Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosa...
UPLC-MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Dec 12, 2017
Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication rates in HCV mono- and HIV/HCV co-infected patients. In this scenery, availability of Therapeutic D...
Development and validation of an LC-MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies.
Journal of food and drug analysis
Nov 11, 2017
ent-16-Oxobeyeran-19-N-methylureido (NC-8) is a recently synthesized derivative of isosteviol that showed anti-hepatitis B virus (HBV) activity by disturbing replication and gene expression of the HBV and by inhibiting the host toll-like receptor 2/n...
QSAR studies of the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by multiple linear regression (MLR) and support vector machine (SVM).
Bioorganic & medicinal chemistry letters
May 3, 2017
In this study, quantitative structure-activity relationship (QSAR) models using various descriptor sets and training/test set selection methods were explored to predict the bioactivity of hepatitis C virus (HCV) NS3/4A protease inhibitors by using a ...
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