AIMC Topic: Apoptosis

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A CNN-aided method to predict glaucoma progression using DARC (Detection of Apoptosing Retinal Cells).

Expert review of molecular diagnostics May 3, 2020
BACKGROUND: A key objective in glaucoma is to identify those at risk of rapid progression and blindness. Recently, a novel first-in-man method for visualising apoptotic retinal cells called DARC (Detection-of-Apoptosing-Retinal-Cells) was reported. T...
Female Aged Adult Male Middle Aged Humans Neural Networks, Computer Glaucoma Algorithms Tomography, Optical Coherence Observer Variation Disease Progression Retinal Ganglion Cells Image Processing, Computer-Assisted Automation Apoptosis Annexin A5 Clinical Trials, Phase II as Topic
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Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.

Pharmacological reports : PR Dec 20, 2019
BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin an...
Xenograft Model Antitumor Assays Neoplasm Metastasis Humans MAP Kinase Signaling System ADAM Proteins Animals Membrane Proteins Neoplasm Invasiveness Mice, SCID Antineoplastic Agents Cell Proliferation Pancreatic Neoplasms Cell Line, Tumor Propofol Matrix Metalloproteinase 9 Cell Movement Matrix Metalloproteinase 2 Apoptosis
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Efficient identification of novel anti-glioma lead compounds by machine learning models.

European journal of medicinal chemistry Dec 19, 2019
Glioblastoma multiforme (GBM) is the most devastating and widespread primary central nervous system tumor. Pharmacological treatment of this malignance is limited by the selective permeability of the blood-brain barrier (BBB) and relies on a single d...
Mice Cell Proliferation Glioma Apoptosis Mice, Inbred C57BL Models, Statistical Xenograft Model Antitumor Assays Machine Learning Humans Tumor Cells, Cultured Female Nitrofurans Animals Male Antineoplastic Agents
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Four transcription profile-based models identify novel prognostic signatures in oesophageal cancer.

Journal of cellular and molecular medicine Nov 19, 2019
Oesophageal cancer (ESCA) is a clinically challenging disease with poor prognosis and health-related quality of life. Here, we investigated the transcriptome of ESCA to identify high risk-related signatures. A total of 159 ESCA patients of The Cancer...
Tumor Cells, Cultured Cell Proliferation Apoptosis Esophageal Neoplasms Esophageal Squamous Cell Carcinoma Algorithms Prognosis Female Survival Rate Biomarkers, Tumor Male Middle Aged Transcriptome Gene Expression Regulation, Neoplastic Humans Machine Learning
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Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data.

PloS one Nov 8, 2019
Several studies have reported mitochondrial dysfunction in rheumatoid arthritis (RA). Many nuclear DNA (nDNA) encoded proteins translocate to mitochondria, but their participation in the dysfunction of this cell organelle during RA is quite unclear. ...
Gene Expression Profiling Protein Interaction Maps Arthritis, Rheumatoid Inflammation Synovial Membrane Apoptosis Reactive Oxygen Species Models, Biological Mitochondria Humans Gene Expression Regulation Gene Ontology Mitochondrial Proteins Oxidative Phosphorylation
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System-level responses to cisplatin in pro-apoptotic stages of breast cancer MCF-7 cell line.

Computational biology and chemistry Nov 2, 2019
Cisplatin ceases cell division and induces apoptosis in cancer cell lines. It is well established that cisplatin alters the expression of many genes involved in several cellular processes and pathways including transcription, p53 signaling pathway, a...
Humans Software Female Breast Neoplasms Gene Expression Regulation, Neoplastic Cell Proliferation Apoptosis Neoplasm Proteins Drug Screening Assays, Antitumor Drug Discovery Antineoplastic Agents Protein Interaction Maps Gene Regulatory Networks MCF-7 Cells Cisplatin Gene Ontology
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Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells.

Nutrition and cancer Sep 5, 2019
Prostate cancer is the most common form of cancer in the male. Epidemiological studies have associated increased cancer incidence with reduced consumption of fruit and vegetables. This study was aimed to investigate the influence of dwarf pomegranat...
Cell Proliferation Humans Apoptosis Male Prostatic Neoplasms Cell Line, Tumor Pomegranate Plant Extracts Fruit
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Automated Classification of Apoptosis in Phase Contrast Microscopy Using Capsule Network.

IEEE transactions on medical imaging May 22, 2019
Automatic and accurate classification of apoptosis, or programmed cell death, will facilitate cell biology research. The state-of-the-art approaches in apoptosis classification use deep convolutional neural networks (CNNs). However, these networks ar...
Cytological Techniques Cells Humans Microscopy, Phase-Contrast Neural Networks, Computer Cell Line, Tumor Image Processing, Computer-Assisted Apoptosis
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Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective.

PloS one Mar 26, 2019
BACKGROUND & AIMS: Current non-invasive scores for the assessment of severity of non-alcoholic fatty liver disease (NAFLD) and identification of patients with non-alcoholic steatohepatitis (NASH) have insufficient performance to be included in clinic...
Male Humans Apoptosis Middle Aged Machine Learning Obesity Biomarkers Cohort Studies Body Weight Female Non-alcoholic Fatty Liver Disease Computational Biology Adult
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Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia.

Oxidative medicine and cellular longevity Dec 18, 2018
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy is involved ...
Ischemic Attack, Transient Microtubule-Associated Proteins Quinolines Transient Receptor Potential Channels Astrocytes Autophagy Neurons Phthalimides Mice Disease Models, Animal Apoptosis Mice, Inbred C57BL Reperfusion Injury Cells, Cultured Animals Male Oxidative Stress
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