AIMC Topic: Autoantibodies
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Identification of distinct blood-based biomarkers in early stage of Parkinson's disease.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Dec 11, 2019
Parkinson's disease (PD) is a slowly progressive geriatric disease, which can be one of the leading causes of serious socioeconomic burden in the aging society. Clinical trials suggest that prompt treatment of early-stage Parkinson's disease (EPD) ma...
Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis.
AJNR. American journal of neuroradiology
Nov 14, 2019
BACKGROUND AND PURPOSE: Limbic encephalitis is an autoimmune disease. A variety of autoantibodies have been associated with different subtypes of limbic encephalitis, whereas its MR imaging signature is uniformly characterized by mesiotemporal abnorm...
On using machine learning algorithms to define clinically meaningful patient subgroups.
Annals of the rheumatic diseases
Jun 21, 2019
Physician Review of a Celiac Disease Risk Estimation and Decision-Making Expert System.
Journal of the American College of Nutrition
May 7, 2019
Celiac disease is a genetic disease affecting people of all ages, resulting in small intestine enteropathy. It is considered to be a clinical chameleon. Average prevalence of celiac disease is 1 out of 100 people with data indicating the risk may be...
Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models.
PloS one
Dec 4, 2018
OBJECTIVE: Limited evidences are available on biomarkers to recognize Systemic Lupus erythematosus (SLE) patients at risk to develop erosive arthritis. Anti-citrullinated peptide antibodies (ACPA) have been widely investigated and identified in up to...
Artificial neural networks help to identify disease subsets and to predict lymphoma in primary Sjögren's syndrome.
Clinical and experimental rheumatology
Aug 14, 2018
OBJECTIVES: Primary Sjögren's syndrome (pSS) is a complex chronic systemic disorder, for which specific and effective therapeutic interventions are still lacking. In this era of precision medicine, there is a clear need for a better definition of dis...
Disease Progression
Severity of Illness Index
Diagnosis, Computer-Assisted
Lymphoma
Risk Factors
Aged
Male
Middle Aged
Data Mining
Serologic Tests
Sjogren's Syndrome
Diagnosis, Differential
Predictive Value of Tests
Principal Component Analysis
Humans
Autoantibodies
Neural Networks, Computer
Decision Support Techniques
Prognosis
Phenotype
Female
Biomarkers
Reproducibility of Results
Glycomics meets artificial intelligence - Potential of glycan analysis for identification of seropositive and seronegative rheumatoid arthritis patients revealed.
Clinica chimica acta; international journal of clinical chemistry
Feb 25, 2018
In this study, one hundred serum samples from healthy people and patients with rheumatoid arthritis (RA) were analyzed. Standard immunoassays for detection of 10 different RA markers and analysis of glycan markers on antibodies in 10 different assay ...
A novel algorithm to improve specificity in ovarian cancer detection.
Cancer treatment and research communications
Nov 10, 2017
BACKGROUND: Measurement of autoantibodies (AAbs) to tumor associated antigens has been proposed to aid in the early detection of ovarian cancer with high specificity. Here we describe a multiplex approach to evaluate selected peptide epitopes of p53 ...
Identification of immune signatures predictive of clinical protection from malaria.
PLoS computational biology
Oct 24, 2017
Antibodies are thought to play an essential role in naturally acquired immunity to malaria. Prospective cohort studies have frequently shown how continuous exposure to the malaria parasite Plasmodium falciparum cause an accumulation of specific respo...
Adequate tacrolimus concentration for myasthenia gravis treatment.
European journal of neurology
Nov 7, 2016
BACKGROUND AND PURPOSE: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti-acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms. How...
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