AIMC Topic: Biomarkers, Tumor

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Rapid diagnosis of TERT promoter mutation using Terahertz absorption spectroscopy in glioblastoma.

Scientific reports
Glioblastoma (GBM) is a highly aggressive brain tumor with poor outcomes and limited treatment options. The telomerase reverse transcriptase (TERT) promoter mutation, one of the key biomarkers in GBM, is linked to tumor progression and prognosis. Thi...

Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision medicine.

Frontiers in immunology
BACKGROUND: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Natural killer (NK) cells play a crucial role in the innate immune system and exhibit significant anti-tumor activity. However, the role of NK c...

Identification and validation of prognostic genes associated with T-cell exhaustion and macrophage polarization in breast cancer.

Frontiers in endocrinology
BACKGROUND: The most frequent malignant tumor in women is breast cancer (BRCA). It has been discovered that T-cell exhaustion and macrophages play significant roles in BRCA. It was necessary to explore prognostic genes associated with T-cell exhausti...

Multiomics in Renal Cell Carcinoma: Current Landscape and Future Directions for Precision Medicine.

Current urology reports
PURPOSE OF REVIEW: Renal cell carcinoma (RCC) is a prevalent and increasingly diagnosed malignancy associated with high mortality and recurrence rates. Traditional diagnostic and therapeutic approaches have limitations due to the disease's molecular ...

The development of predictive biomarkers and immunologic markers for breast cancer: current status and future perspectives.

Brazilian journal of biology = Revista brasleira de biologia
Breast cancer is the leading cause of cancer-related mortality among women worldwide. The development of predictive biomarkers and immunologic markers has revolutionized breast cancer diagnosis and treatment, enabling personalized medicine approaches...

Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.

International journal of molecular sciences
Liquid biopsy has gained attention in oncology as a non-invasive diagnostic tool, offering valuable insights into tumor biology through the analysis of circulating nucleic acid (cfDNA and cfRNA), circulating tumor cells (CTCs), extracellular vesicles...

Single-cell multimodal analysis reveals tumor microenvironment predictive of treatment response in non-small cell lung cancer.

Science advances
Non-small cell lung cancer (NSCLC) constitutes over 80% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Despite the advent of immune checkpoint inhibitors, their efficacy is limited to 27 to 45% of patients. Id...

Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer.

Frontiers in immunology
INTRODUCTION: Pancreatic cancer (PC) remains a lethal malignancy with limited treatment options. The role of innate immune cell barrier-related genes in PC prognosis is poorly defined. This study aimed to identify prognostic biomarkers, develop a pre...

Plasma and Urine Circulating Tumor DNA Methylation Profiles for Non-Invasive Pancreatic Ductal Adenocarcinoma Detection: Significant Findings in Plasma Only.

International journal of molecular sciences
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment options, and early detection remains challenging due to the lack of reliable non-invasive biomarkers. This study investigated plasma and urine circulating tumor deo...