AIMC Topic: Biomarkers

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Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME/CFS progression.

Frontiers in immunology
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition with no identified diagnostic biomarkers to date. Its prevalence is as high as 0.89% according to metastudies, with a quarter of patients bed-...

The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers.

Expert review of molecular diagnostics
INTRODUCTION: Pancreatic cancer (PC) has an extremely poor prognosis, even with surgical resection and triplet chemotherapy treatment. Cancer immunotherapy has been recently approved for tumor-agnostic treatment with genome analysis, including in PC....

Predictive value of preoperative Fried Frailty Phenotype assessment and serum biomarkers on the prognosis of elderly patients with femoral neck fracture under general anesthesia within 3 months after surgery.

Turkish journal of medical sciences
BACKGROUND/AIM: Femoral neck fracture (FNF) seriously impact the health of the elderly and affect their long-term quality of life of the patients. This study aimed to determine whether combining the preoperative Fried Frailty Phenotype (FFP) with ser...

A machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitis.

Scientific reports
Over the past decade, automation of digital image analysis has become commonplace in both research and clinical settings. Spurred by recent advances in artificial intelligence and machine learning (AI/ML), tissue sub-compartments and cellular phenoty...

Moderate wine consumption measured using the biomarker urinary tartaric acid concentration decreases inflammatory mediators related to atherosclerosis.

The journal of nutrition, health & aging
OBJECTIVES: Several studies suggest that moderate wine consumption, particularly red wine, may have benefits for cardiovascular health. Red wine contains a variety of bioactive compounds, including polyphenols like phenolic acids, which have demonstr...

Identification of sudden cardiac death from human blood using ATR-FTIR spectroscopy and machine learning.

International journal of legal medicine
OBJECTIVE: The aim of this study is to identify a rapid, sensitive, and non-destructive auxiliary approach for postmortem diagnosis of SCD, addressing the challenges faced in forensic practice.

Ensemble machine learning model trained on a new synthesized dataset generalizes well for stress prediction using wearable devices.

Journal of biomedical informatics
INTRODUCTION: Advances in wearable sensor technology have enabled the collection of biomarkers that may correlate with levels of elevated stress. While significant research has been done in this domain, specifically in using machine learning to detec...

BioDiscViz: A visualization support and consensus signature selector for BioDiscML results.

PloS one
Machine learning (ML) algorithms are powerful tools to find complex patterns and biomarker signatures when conventional statistical methods fail to identify them. While the ML field made significant progress, state of the art methodologies to build e...

Opportunistic assessment of ischemic heart disease risk using abdominopelvic computed tomography and medical record data: a multimodal explainable artificial intelligence approach.

Scientific reports
Current risk scores using clinical risk factors for predicting ischemic heart disease (IHD) events-the leading cause of global mortality-have known limitations and may be improved by imaging biomarkers. While body composition (BC) imaging biomarkers ...

Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and artificial intelligence strategies.

Lipids in health and disease
BACKGROUND: Intervertebral disc degeneration (IVDD) is widely recognized as the primary etiological factor underlying low back pain, often necessitating surgical intervention as the sole recourse in severe cases. The metabolic pathway of arachidonic ...