AIMC Topic: Blood-Brain Barrier

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Identification of Key Features of CNS Drugs Based on SVM and Greedy Algorithm.

Current computer-aided drug design Jan 1, 2020
INTRODUCTION: The research and development of drugs, related to the central nervous system (CNS) diseases is a long and arduous process with high cost, long cycle and low success rate. Identification of key features based on available CNS drugs is of...
Humans Algorithms Computer Simulation Blood-Brain Barrier Support Vector Machine Pharmaceutical Preparations Drug Evaluation, Preclinical Ligands Central Nervous System Guanidines
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Blood Brain Barrier Permeability Prediction Using Machine Learning Techniques: An Update.

Current pharmaceutical biotechnology Jan 1, 2019
Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and e...
Humans Machine Learning Brain Blood-Brain Barrier Animals Drug Development Pharmaceutical Preparations Models, Biological Diffusion Permeability Endothelial Cells Capillary Permeability
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A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Current pharmaceutical biotechnology Jan 1, 2017
BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.
Humans Blood-Brain Barrier Drug Delivery Systems Animals Nanoparticles Rats Mice, Nude Drug Carriers RNA, Small Interfering Neurons Alzheimer Disease Permeability Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Molecular Targeted Therapy PC12 Cells Gene Knockdown Techniques
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