AIMC Topic: Carcinoma, Pancreatic Ductal

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Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer.

Cancer immunology research May 2, 2024
Tumor molecular data sets are becoming increasingly complex, making it nearly impossible for humans alone to effectively analyze them. Here, we demonstrate the power of using machine learning (ML) to analyze a single-cell, spatial, and highly multipl...
T-Lymphocytes Male Immunotherapy Machine Learning Female Tumor Microenvironment Pancreatic Neoplasms Carcinoma, Pancreatic Ductal CD40 Antigens Treatment Outcome Neoadjuvant Therapy Lymphocytes, Tumor-Infiltrating Humans
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Eravacycline, an antibacterial drug, repurposed for pancreatic cancer therapy: insights from a molecular-based deep learning model.

Briefings in bioinformatics Mar 27, 2024
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains a serious threat to health, with limited effective therapeutic options, especially due to advanced stage at diagnosis and its inherent resistance to chemotherapy, making it one of the leadin...
Humans Apoptosis Pancreatic Neoplasms Drug Repositioning Cell Line, Tumor Carcinoma, Pancreatic Ductal Anti-Bacterial Agents Cell Proliferation Tetracyclines Antineoplastic Agents Cell Movement Deep Learning
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[Survival of patients with pancreatic ductal adenocarcinoma].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru Jan 1, 2023
OBJECTIVE: The objective of this study is to analyze the epidemiological presentation and survival of patients with pancreatic ductal adenocarcinoma according to their clinical stage and the type of intervention performed, in a cohort of patients tre...
Humans Prognosis Neoadjuvant Therapy Retrospective Studies Pancreatic Neoplasms Carcinoma, Pancreatic Ductal
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Machine learning analyses of highly-multiplexed immunofluorescence identifies distinct tumor and stromal cell populations in primary pancreatic tumors.

Cancer biomarkers : section A of Disease markers Jan 1, 2022
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a formidable challenge for patients and clinicians.
Image Interpretation, Computer-Assisted Stromal Cells Fluorescent Antibody Technique Tumor Microenvironment Biomarkers, Tumor Male Middle Aged Pancreatic Neoplasms Carcinoma, Pancreatic Ductal Female Aged Aged, 80 and over Humans Machine Learning
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Predicting pancreatic ductal adenocarcinoma using artificial intelligence analysis of pre-diagnostic computed tomography images.

Cancer biomarkers : section A of Disease markers Jan 1, 2022
BACKGROUND: Early stage diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC) is challenging due to the lack of specific diagnostic biomarkers. However, stratifying individuals at high risk of PDAC, followed by monitoring their health conditions on re...
Humans Artificial Intelligence Tomography, X-Ray Computed Bayes Theorem Carcinoma, Pancreatic Ductal Abdomen Early Detection of Cancer Pancreatic Neoplasms
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Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review.

Pancreas Mar 1, 2021
Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly nonspecific. The premise of improved survival through early detection is tha...
Interdisciplinary Communication Biomarkers, Tumor Genomics Humans Early Detection of Cancer Pancreatic Neoplasms Artificial Intelligence Prognosis Carcinoma, Pancreatic Ductal Survival Analysis
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Application of Deep Learning to Pancreatic Cancer Detection: Lessons Learned From Our Initial Experience.

Journal of the American College of Radiology : JACR Sep 1, 2019
Male Case-Control Studies Deep Learning Imaging, Three-Dimensional Pancreatic Neoplasms Workflow Retrospective Studies Tomography, X-Ray Computed Female Humans Carcinoma, Pancreatic Ductal Forecasting Quality Improvement Automation
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Usefulness of Deep Learning Analysis for the Diagnosis of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Clinical and translational gastroenterology May 22, 2019
OBJECTIVES: Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic adenocarcinoma. Artificial intelligence (AI) is a mathematical concept whose implementation automates learning and recognizing data patterns. The aim of ...
Deep Learning Pancreatic Intraductal Neoplasms ROC Curve Image Processing, Computer-Assisted Humans Male Pancreas Retrospective Studies Pancreatic Neoplasms Middle Aged Pancreatectomy Female Carcinoma, Pancreatic Ductal Disease Progression Preoperative Period Aged Endosonography Aged, 80 and over Adult
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