AIMC Topic: CD8-Positive T-Lymphocytes

Clear Filters Showing 21 to 30 of 43 articles

PTPRC promoted CD8+ T cell mediated tumor immunity and drug sensitivity in breast cancer: based on pan-cancer analysis and artificial intelligence modeling of immunogenic cell death-based drug sensitivity stratification.

Frontiers in immunology Jun 14, 2023
BACKGROUND: Immunogenic cell death (ICD) is a result of immune cell infiltration (ICI)-mediated cell death, which is also a novel acknowledgment to regulate cellular stressor-mediated cell death, including drug therapy and radiotherapy.
CD8-Positive T-Lymphocytes Drug Resistance Leukocyte Common Antigens Immunogenic Cell Death Humans Artificial Intelligence Triple Negative Breast Neoplasms
View on PubMed DOI

Anti-Colorectal Cancer Effects of (Bull.: Fr.) P. Karst. Spore Powder through Regulation of Gut Microbiota-Mediated JAK/STAT Signaling.

Nutrients Aug 12, 2022
(Bull.: Fr.) P. Karst. spore powder (IHS) contains polyphenols and triterpenoids with pharmacological effects. Here, we analyzed its composition, and we investigated the effects of IHS on colorectal cancer (CRC) in B6/JGpt-/Gpt () mice and its poten...
Inonotus Animals Gastrointestinal Microbiome Janus Kinases Neoplasms CD8-Positive T-Lymphocytes Spores Mice Powders
View on PubMed DOI

Development of a Fully Automated Method to Obtain Reproducible Lymphocyte Counts in Patients With Colorectal Cancer.

Applied immunohistochemistry & molecular morphology : AIMM Jun 15, 2022
Colorectal cancer (CRC) is the third most common cancer worldwide. Although clinical outcome varies among patients diagnosed within the same TNM stage it is the cornerstone in treatment decisions as well as follow-up programmes. Tumor-infiltrating ly...
Lymphocytes, Tumor-Infiltrating CD8-Positive T-Lymphocytes Lymphocyte Count Humans Artificial Intelligence Colorectal Neoplasms
View on PubMed DOI

Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions.

Scientific reports Jan 11, 2022
Identification of cognate interactions between antigen-specific T cells and dendritic cells (DCs) is essential to understanding immunity and tolerance, and for developing therapies for cancer and autoimmune diseases. Conventional techniques for selec...
Animals Video Recording Mice, Inbred C57BL CD8-Positive T-Lymphocytes Cell Communication Deep Learning Dendritic Cells Mice
View on PubMed DOI

Deep Learning of Morphologic Correlations To Accurately Classify CD4+ and CD8+ T Cells by Diffraction Imaging Flow Cytometry.

Analytical chemistry Jan 10, 2022
The two major subtypes of human T cells, CD4+ and CD8+, play important roles in adaptive immune response by their diverse functions. To understand the structure-function relation at the single cell level, we isolated 2483 CD4+ and 2450 CD8+ T cells f...
Humans Neural Networks, Computer Flow Cytometry CD4-Positive T-Lymphocytes Deep Learning CD8-Positive T-Lymphocytes
View on PubMed DOI

Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathway.

Oncoimmunology Nov 26, 2021
Kynurenine (Kyn) is a key inducer of an immunosuppressive tumor microenvironment (TME). Although indoleamine 2,3-dioxygenase (IDO)-selective inhibitors have been developed to suppress the Kyn pathway, the results were not satisfactory due to the pres...
Deep Learning Kynurenine Immunotherapy CD8-Positive T-Lymphocytes Indoleamine-Pyrrole 2,3,-Dioxygenase
View on PubMed DOI

Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning.

Frontiers in immunology Jun 28, 2021
Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being investigated. Here, we explored the role of CCR5 and its ligands across the immunologic spectrum of CO...
RNA, Viral T-Lymphocytes, Regulatory Receptors, CCR5 Chemokine CCL5 Computational Biology CD8-Positive T-Lymphocytes Post-Acute COVID-19 Syndrome Case-Control Studies Lymphocyte Activation Antibodies, Viral COVID-19 Algorithms Prognosis Male Severity of Illness Index Female SARS-CoV-2 Humans Machine Learning
View on PubMed DOI

Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response.

Frontiers in immunology Feb 18, 2021
Predictive models are becoming more and more commonplace as tools for candidate antigen discovery to meet the challenges of enabling epitope mapping of cohorts with diverse HLA properties. Here we build on the concept of using two key parameters, div...
Proteome CD8-Positive T-Lymphocytes HLA Antigens Epitopes, T-Lymphocyte Peptides HIV Infections Genome, Viral Viral Proteins Antigens, Viral HIV Genetic Variation Host-Pathogen Interactions Humans Machine Learning
View on PubMed DOI

Calculation of immune cell proportion from batch tumor gene expression profile based on support vector regression.

Journal of bioinformatics and computational biology Aug 21, 2020
In addition to tumor cells, a large number of immune cells are found in the tumor microenvironment (TME) of cancer patients. Tumor-infiltrating immune cells play an important role in tumor progression and patient outcome. We improved the relative pro...
Gene Expression Regulation, Neoplastic Neutrophils Support Vector Machine Immunohistochemistry CD8-Positive T-Lymphocytes Flow Cytometry Colorectal Neoplasms Tumor Microenvironment Gene Expression Profiling Humans Algorithms Databases, Factual
View on PubMed DOI

High-Throughput Prediction of MHC Class I and II Neoantigens with MHCnuggets.

Cancer immunology research Dec 23, 2019
Computational prediction of binding between neoantigen peptides and major histocompatibility complex (MHC) proteins can be used to predict patient response to cancer immunotherapy. Current neoantigen predictors focus on estimation of MHC binding aff...
Protein Binding Computational Biology Cancer Vaccines Software Algorithms Neoplasms Histocompatibility Antigens Class I Humans Data Mining Neural Networks, Computer Mutation, Missense Artificial Intelligence Histocompatibility Antigens Class II Antigens, Neoplasm CD8-Positive T-Lymphocytes Predictive Value of Tests
View on PubMed DOI
Popular Topics
Recent Journals