AIMC Topic: Cell Communication

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A Graph Based Neural Network Approach to Immune Profiling of Multiplexed Tissue Samples.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Multiplexed immunofluorescence provides an un-precedented opportunity for studying specific cell-to-cell and cell microenvironment interactions. We employ graph neural networks to combine features obtained from tissue morphology with measurements of ...

LR-GNN: a graph neural network based on link representation for predicting molecular associations.

Briefings in bioinformatics
In biomedical networks, molecular associations are important to understand biological processes and functions. Many computational methods, such as link prediction methods based on graph neural networks (GNNs), have been successfully applied in discov...

DeepTrio: a ternary prediction system for protein-protein interaction using mask multiple parallel convolutional neural networks.

Bioinformatics (Oxford, England)
MOTIVATION: Protein-protein interaction (PPI), as a relative property, is determined by two binding proteins, which brings a great challenge to design an expert model with an unbiased learning architecture and a superior generalization performance. A...

Epitome: predicting epigenetic events in novel cell types with multi-cell deep ensemble learning.

Nucleic acids research
The accumulation of large epigenomics data consortiums provides us with the opportunity to extrapolate existing knowledge to new cell types and conditions. We propose Epitome, a deep neural network that learns similarities of chromatin accessibility ...

Artificial intelligence and the hunt for immunological disorders.

Current opinion in allergy and clinical immunology
PURPOSE OF REVIEW: Artificial intelligence has pervasively transformed many industries and is beginning to shape medical practice. New use cases are being identified in subspecialty domains of medicine and, in particular, application of artificial in...

Synthetic biology routes to bio-artificial intelligence.

Essays in biochemistry
The design of synthetic gene networks (SGNs) has advanced to the extent that novel genetic circuits are now being tested for their ability to recapitulate archetypal learning behaviours first defined in the fields of machine and animal learning. Here...

Schwann Cell and Axon: An Interlaced Unit-From Action Potential to Phenotype Expression.

Advances in experimental medicine and biology
Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence in several fields and show ...