AIMC Topic: Cellular Senescence
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A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids.
Cancer biology & medicine
Jun 30, 2023
OBJECTIVE: Organoids are a powerful tool with broad application prospects in biomedicine. Notably, they provide alternatives to animal models for testing potential drugs before clinical trials. However, the number of passages for which organoids main...
[Role of high mobility group protein B1 in IL-1α-induced endothelial cell senescence].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Dec 28, 2017
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
Methods: HUVECs were randomly divided into a control group, a IL-1α group...
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.
Neoplasia (New York, N.Y.)
Sep 1, 2015
Cellular senescence is a barrier to tumorigenesis in normal cells, and tumor cells undergo senescence responses to genotoxic stimuli, which is a potential target phenotype for cancer therapy. However, in this setting, mixed-mode responses are common ...
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