AIMC Topic: Circadian Rhythm
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Identification of human circadian genes based on time course gene expression profiles by using a deep learning method.
Biochimica et biophysica acta. Molecular basis of disease
Dec 12, 2017
Circadian genes express periodically in an approximate 24-h period and the identification and study of these genes can provide deep understanding of the circadian control which plays significant roles in human health. Although many circadian gene ide...
Daily changes of individual gait patterns identified by means of support vector machines.
Gait & posture
Jul 29, 2016
Despite the common knowledge about the individual character of human gait patterns and about their non-repeatability, little is known about their stability, their interactions and their changes over time. Variations of gait patterns are typically des...
Can Lionel Messi's brain slow down time passing?
Chronobiology international
Mar 24, 2016
It seems that seeing others in slow-motion by heroes does not belong only to movies. When Lionel Messi plays football, you can hardly see anything from him that other players cannot do. Then why he is not stoppable really? It seems the answer may be ...
Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.
Clinical pharmacology in drug development
Jun 8, 2015
BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone (TT) concentration. The objective of the present analysis was to define ...
Fourier Analysis
London
Selective Estrogen Receptor Modulators
Benzopyrans
Drug Administration Schedule
Estrogen Receptor beta
Single-Blind Method
Administration, Oral
Models, Biological
Adult
Cross-Over Studies
Humans
Circadian Rhythm
Male
Healthy Volunteers
Biomarkers
Middle Aged
Nonlinear Dynamics
Young Adult
Testosterone
Recognition of activities of daily living in healthy subjects using two ad-hoc classifiers.
Biomedical engineering online
Jun 6, 2015
BACKGROUND: Activities of daily living (ADL) are important for quality of life. They are indicators of cognitive health status and their assessment is a measure of independence in everyday living. ADL are difficult to reliably assess using questionna...
Big data approaches for novel mechanistic insights on sleep and circadian rhythms: a workshop summary.
Sleep
Jun 13, 2025
The National Center on Sleep Disorders Research of the National Heart, Lung, and Blood Institute at the National Institutes of Health hosted a 2-day virtual workshop titled Big Data Approaches for Novel Mechanistic Insights on Disorders of Sleep and ...
Diagnostic performance of actigraphy in Alzheimer's disease using a machine learning classifier - a cross-sectional memory clinic study.
Alzheimer's research & therapy
May 21, 2025
BACKGROUND: Movement patterns, activity levels and circadian rhythm are altered in Alzheimer's disease (AD) and can be assessed by actigraphy using wearable sensors. We aimed to determine the diagnostic performance of actigraphy in AD in a memory cli...
A circadian behavioral analysis suite for real-time classification of daily rhythms in complex behaviors.
Cell reports methods
May 19, 2025
Long-term analysis of animal behavior has been limited by reliance on real-time sensors or manual scoring. Existing machine learning tools can automate analysis but often fail under variable conditions or ignore temporal dynamics. We developed a scal...
Prognostic value of circadian rhythm-associated genes in breast cancer.
World journal of surgical oncology
May 14, 2025
OBJECTIVE: Breast cancer (BC) remains the most prevalent malignancy among women. Clinical evidence indicates that genetic variations related to circadian rhythms, as well as the timing of therapeutic interventions, influence the response to radiation...
Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data.
Scientific reports
May 10, 2025
Restless legs syndrome (RLS) is a relatively common neurosensory disorder that causes an irresistible urge for leg movement. RLS causes sleep disturbances and reduced quality of life, but accurate diagnosis remains challenging owing to the reliance o...
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