AIMC Topic: Colorectal Neoplasms

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Renji endoscopic submucosal dissection video data set for colorectal neoplastic lesions.

Scientific data
Artificial intelligence advancements have significantly enhanced computer-aided intervention, learning among surgeons, and analysis of surgical videos post-operation, substantially elevating surgical expertise and patient outcomes. Recognition system...

Personalized colorectal cancer risk assessment through explainable AI and Gut microbiome profiling.

Gut microbes
The clinical adenoma - carcinoma progression represents a well-established framework for understanding colorectal cancer (CRC) development, although the molecular mechanisms underlying this transition remain only partially understood. Increasing evid...

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer.

Scientific reports
Colorectal cancer (CRC) treatment remains challenging due to genetic heterogeneity and resistance mechanisms. To address this, we developed a drug discovery pipeline using patient-derived primary CRC cultures with diverse genomic profiles. These cult...

Exploring doctors' perspectives on precision medicine and AI in colorectal cancer: opportunities and challenges for the doctor-patient relationship.

BMC medical informatics and decision making
BACKGROUND: Precision medicine and artificial intelligence (AI) are increasingly integrated into colorectal cancer (CRC) care, offering personalised treatment strategies and data-driven decision support. While these technologies promise improved outc...

Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case-control development and validation study (COBRA2 study).

BMC cancer
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in the United Kingdom. The five-year survival rate from CRC is only 10% when discovered at a late stage, but can exceed 90% if diagnosed early. Symptoms related to CRC can be non-sp...

Ferroptosis-disulfidptosis-related CHMP6 is a clinico-immune target in colorectal cancer.

Biology direct
BACKGROUND: Ferroptosis and disulfidptosis are newly discovered forms of regulated cell death that play critical roles in cancer progression, metabolism, and immune evasion. However, their interplay and combined influence on colorectal cancer (CRC) p...

Nanopore full length 16S rRNA gene sequencing increases species resolution in bacterial biomarker discovery.

Scientific reports
Discovery of disease-related bacterial biomarkers could be a useful approach for early prevention or diagnosis of various afflictions, such as colorectal cancer. This typically involves analyzing small regions of the 16S rRNA gene (e.g. V3V4) through...

Performance of Machine Learning in Diagnosing KRAS (Kirsten Rat Sarcoma) Mutations in Colorectal Cancer: Systematic Review and Meta-Analysis.

Journal of medical Internet research
BACKGROUND: With the widespread application of machine learning (ML) in the diagnosis and treatment of colorectal cancer (CRC), some studies have investigated the use of ML techniques for the diagnosis of KRAS (Kirsten rat sarcoma) mutation. Neverthe...

Machine learning to evaluate the effects of non-clinical social determinant features in predicting colorectal Cancer mortality in a medically underserved Appalachian population.

Scientific reports
Colorectal cancer (CRC) is the 2nd leading cause of cancer death in the United States (US). Rural Appalachia suffers the highest CRC incidence and mortality rates. There are several non-clinical health-related social determinant factors (SDOH) associ...

Using machine learning algorithms to predict risk factors of heart failure after complete mesocolic excision in colorectal cancer patients.

Scientific reports
Following complete mesocolic excision (CME), heart failure (HF) emerges as a significant complication, exerting substantial impacts on both short-term and long-term patient prognoses. The primary objective of our investigation was to develop a machin...