AIMC Topic: Cyclin-Dependent Kinase 6

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Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.

BMC cancer May 8, 2025
BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized controlled trials involving the...
Cyclin-Dependent Kinase 6 Receptor, ErbB-2 Receptors, Estrogen Network Meta-Analysis as Topic Aromatase Inhibitors Antineoplastic Combined Chemotherapy Protocols Purines Aminopyridines Protein Kinase Inhibitors Treatment Outcome Receptors, Progesterone Benzimidazoles Randomized Controlled Trials as Topic Cyclin-Dependent Kinase 4 Humans Progression-Free Survival Female Breast Neoplasms
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Insights into phosphorylation-induced influences on conformations and inhibitor binding of CDK6 through GaMD trajectory-based deep learning.

Physical chemistry chemical physics : PCCP Mar 26, 2025
The phosphorylation of residue T177 produces a significant effect on the conformational dynamics of CDK6. Gaussian accelerated molecular dynamics (GaMD) simulations followed by deep learning (DL) are applied to explore the molecular mechanism of the ...
Thermodynamics Cyclin-Dependent Kinase 6 Humans Deep Learning Protein Binding Phosphorylation Molecular Dynamics Simulation Protein Conformation Protein Kinase Inhibitors
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Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer.

Oncogene Feb 26, 2025
CDK4/6 inhibitors in combination with endocrine therapy are widely used to treat HR+/HER2- metastatic breast cancer leading to improved progression-free survival (PFS) compared to single agent endocrine therapy. Over 300 patients receiving standard-o...
Prognosis Female Aged Adult Humans Machine Learning Cyclin-Dependent Kinase 6 Progression-Free Survival Neoplasm Metastasis Protein Kinase Inhibitors Cyclin-Dependent Kinase 4 Breast Neoplasms Middle Aged Gene Expression Regulation, Neoplastic
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Using bioinformatics and artificial intelligence to map the cyclin-dependent kinase 4/6 inhibitor biomarker landscape in breast cancer.

Future oncology (London, England) Nov 12, 2024
A cyclin-dependent kinase 4/6 (CDK4/6) inhibitor combined with endocrine therapy is the standard-of-care for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer. However, not all patients r...
Biomarkers, Tumor Computational Biology Drug Resistance, Neoplasm Protein Kinase Inhibitors Artificial Intelligence Female Breast Neoplasms Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Humans
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Unveiling Conformational States of CDK6 Caused by Binding of Vcyclin Protein and Inhibitor by Combining Gaussian Accelerated Molecular Dynamics and Deep Learning.

Molecules (Basel, Switzerland) Jun 5, 2024
CDK6 plays a key role in the regulation of the cell cycle and is considered a crucial target for cancer therapy. In this work, conformational transitions of CDK6 were identified by using Gaussian accelerated molecular dynamics (GaMD), deep learning (...
Normal Distribution Cyclin-Dependent Kinase 6 Deep Learning Protein Binding Principal Component Analysis Protein Conformation Humans Molecular Dynamics Simulation Protein Kinase Inhibitors Binding Sites Thermodynamics
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A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors.

Nature cancer Mar 5, 2024
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is) have revolutionized breast cancer therapy. However, <50% of patients have an objective response, and nearly all patients develop resistance during therapy. To elucidate the underlying mechanisms, ...
Humans Female Breast Neoplasms Animals Deep Learning Cell Line, Tumor Mice Pyridines Protein Kinase Inhibitors Piperazines Cyclin-Dependent Kinase 4 Xenograft Model Antitumor Assays Cyclin-Dependent Kinase 6 Drug Resistance, Neoplasm
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Artificial Intelligence Approach to Find Lead Compounds for Treating Tumors.

The journal of physical chemistry letters Jul 22, 2019
It has been demonstrated that MMP13 enzyme is related to most cancer cell tumors. The world's largest traditional Chinese medicine database was applied to screen for structure-based drug design and ligand-based drug design. To predict drug activity, ...
Machine Learning Proto-Oncogene Proteins c-mdm2 Algorithms Databases, Protein Proto-Oncogene Proteins c-bcl-2 Cyclin-Dependent Kinase 6 Antineoplastic Agents Peptides Models, Molecular Tumor Suppressor Protein p53 Databases, Pharmaceutical Drug Design Deep Learning Mutation Binding Sites Matrix Metalloproteinase 13 Ligands Cyclin-Dependent Kinase Inhibitor p16 Proteins
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Drug-Drug interactions and special considerations in breast cancer patients treated with CDK4/6 inhibitors: A comprehensive review.

Cancer treatment reviews Jun 1, 2025
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have reshaped the treatment paradigm of hormone receptor positive (HR + )/HER2-negative breast cancer in both adjuvant and metastatic settings. However, their metabolism via the cytochrome P450 (CYP3A4...
Female Breast Neoplasms Antineoplastic Agents Pyridines Humans Purines Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Aminopyridines Piperazines Drug Interactions Protein Kinase Inhibitors Benzimidazoles
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How Artificial Intelligence Unravels the Complex Web of Cancer Drug Response.

Cancer research Jun 4, 2024
The intersection of precision medicine and artificial intelligence (AI) holds profound implications for cancer treatment, with the potential to significantly advance our understanding of drug responses based on the intricate architecture of tumor cel...
Neoplasms Antineoplastic Agents Deep Learning Drug Resistance, Neoplasm Protein Kinase Inhibitors Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Artificial Intelligence Precision Medicine Female Breast Neoplasms Humans
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