AIMC Topic: Proto-Oncogene Proteins c-bcl-2
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Machine learning driven dashboard for chronic myeloid leukemia prediction using protein sequences.
PloS one
Jun 18, 2025
The prevalence of Leukaemia, a malignant blood cancer that originates from hematopoietic progenitor cells, is increasing in Southeast Asia, with a worrisome fatality rate of 54%. Predicting outcomes in the early stages is vital for improving the chan...
Targeting protein-ligand neosurfaces with a generalizable deep learning tool.
Nature
Jan 15, 2025
Molecular recognition events between proteins drive biological processes in living systems. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules. Despite recent advanc...
Novel drug discovery: Advancing Alzheimer's therapy through machine learning and network pharmacology.
European journal of pharmacology
May 23, 2024
Alzheimer's disease (AD), marked by tau tangles and amyloid-beta plaques, leads to cognitive decline. Despite extensive research, its complex etiology remains elusive, necessitating new treatments. This study utilized machine learning (ML) to analyze...
Virtual Screening of Small Molecules Targeting BCL2 with Machine Learning, Molecular Docking, and MD Simulation.
Biomolecules
May 1, 2024
This study aimed to identify potential BCL-2 small molecule inhibitors using deep neural networks (DNN) and random forest (RF), algorithms as well as molecular docking and molecular dynamics (MD) simulations to screen a library of small molecules. Th...
Translating prognostic quantification of c-MYC and BCL2 from tissue microarrays to whole slide images in diffuse large B-cell lymphoma using deep learning.
Diagnostic pathology
Jan 19, 2024
BACKGROUND: c-MYC and BCL2 positivity are important prognostic factors for diffuse large B-cell lymphoma. However, manual quantification is subject to significant intra- and inter-observer variability. We developed an automated method for quantificat...
Deep Learning Reconstruction Algorithm-Based MRI Image Evaluation of Edaravone in the Treatment of Lower Limb Ischemia-Reperfusion Injury.
Contrast media & molecular imaging
Aug 31, 2022
This research aimed to evaluate the therapeutic effect of edaravone on lower limb ischemia-reperfusion injury by MRI images of graph patch-based directional curvelet transform (GPBDCT), compression reconstruction algorithm. 200 patients with lower li...
Artificial Intelligence Approach to Find Lead Compounds for Treating Tumors.
The journal of physical chemistry letters
Jul 22, 2019
It has been demonstrated that MMP13 enzyme is related to most cancer cell tumors. The world's largest traditional Chinese medicine database was applied to screen for structure-based drug design and ligand-based drug design. To predict drug activity, ...
Tumor Suppressor Protein p53
Binding Sites
Proto-Oncogene Proteins c-mdm2
Cyclin-Dependent Kinase 6
Databases, Pharmaceutical
Models, Molecular
Machine Learning
Matrix Metalloproteinase 13
Cyclin-Dependent Kinase Inhibitor p16
Mutation
Algorithms
Ligands
Peptides
Proteins
Proto-Oncogene Proteins c-bcl-2
Drug Design
Databases, Protein
Antineoplastic Agents
Deep Learning
Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels.
Environmental toxicology
Apr 6, 2015
Because of unique optical behavior gold nanorods (GNRs) have attracted attention for the application in biomedical field such as bio-sensing, bio-imaging and hyperthermia. However, toxicological response of GNRs is controversial due to their differen...
Apoptosis
Reactive Oxygen Species
Caspase 3
Particle Size
Acetylcysteine
Proto-Oncogene Proteins c-bcl-2
Humans
Breast Neoplasms
Caspase 9
Down-Regulation
Female
Real-Time Polymerase Chain Reaction
G1 Phase Cell Cycle Checkpoints
RNA, Messenger
Up-Regulation
MCF-7 Cells
Nanotubes
Gold
Membrane Potential, Mitochondrial
Platinum
Synthesis and evaluation of a novel nanosized anionic linear globular dendrimer G2-ciprofloxacin conjugate against prostate cancer.
Pakistan journal of pharmaceutical sciences
Nov 1, 2020
Prostate cancer is the second most common cancer in the world and the fifth cause of cancer deaths in men. Ciprofloxacin enables the inhabitation of the development of prostate cancer. In this regard, we plan to improve the anticancer effect of cipro...
Astragalus Polysaccharide Inhibits Autophagy and Apoptosis from Peroxide-Induced Injury in C2C12 Myoblasts.
Cell biochemistry and biophysics
Nov 1, 2015
The aim is to study the effects and underlying mechanisms of astragalus polysaccharide (APS) on the peroxide-induced injury in C2C12 myoblasts in vitro. Cell viability in the presence or absence of APS was detected by the methyl thiazolyl tetrazolium...
Apoptosis
Cell Line
Cell Survival
Caspase 3
Blotting, Western
Autophagy
TOR Serine-Threonine Kinases
Animals
Cytochromes c
Hydrogen Peroxide
Myoblasts
Ribosomal Protein S6 Kinases, 70-kDa
bcl-2-Associated X Protein
Mice
Microscopy, Electron
Polysaccharides
Signal Transduction
Microtubule-Associated Proteins
Proto-Oncogene Proteins c-bcl-2
Astragalus Plant
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