The Gene Ontology (GO) is widely recognised as the gold standard bioinformatics resource for summarizing functional knowledge of gene products in a consistent and computable, information-rich language. GO describes cellular and organismal processes a...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2016
Genes and their protein products are essential molecular units of a living organism. The knowledge of their functions is key for the understanding of physiological and pathological biological processes, as well as in the development of new drugs and ...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2016
Gene Ontology (GO) is a structured repository of concepts (GO Terms) that are associated to one or more gene products through a process referred to as annotation. The analysis of annotated data is an important opportunity for bioinformatics. There ar...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2016
This chapter presents an introduction to data mining with machine learning. It gives an overview of various types of machine learning, along with some examples. It explains how to download, install, and run the WEKA data mining toolkit on a simple da...
IEEE/ACM transactions on computational biology and bioinformatics
Jan 1, 2016
In recent years, thanks to the efforts of individual scientists and research consortiums, a huge amount of chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) experimental data have been accumulated. Instead of investigati...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2016
We have previously developed a statistical method to identify gene sets enriched with condition-specific genetic dependencies. The method constructs gene dependency networks from bootstrapped samples in one condition and computes the divergence betwe...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2016
The use of controlled, structured vocabularies (ontologies) has become a critical tool for scientists in the post-genomic era of massive datasets. Adoption and integration of common vocabularies and annotation practices enables cross-species comparat...
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Jan 1, 2016
OBJECTIVES: Serous borderline ovarian tumors (SBOTs) are a subtype of serous ovarian carcinoma with atypical proliferation. Frozen-section diagnosis has been used as an intraoperative diagnosis tool in supporting the fertility-sparing surgery by diag...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2016
Cellular phenotypes result from the combined effect of multiple genes, and high-throughput techniques such as DNA microarrays and deep sequencing allow monitoring this genomic complexity. The large scale of the resulting data, however, creates challe...