PurposeTo identify parameters that are significant risk predictors of visual field (VF) progression in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG), using Goldmann applanation tonometry intraocular pressure (IOP...
A significant barrier to developing disease-modifying therapies for spinocerebellar ataxias (SCAs) and multiple system atrophy of the cerebellar type (MSA-C) is the scarcity of tools to measure disease progression sensitively in clinical trials. Wear...
BACKGROUND: Predicting shorter life expectancy is crucial for prioritising antifibrotic therapy in fibrotic lung diseases (FLDs), where progression varies widely, from stability to rapid deterioration. This heterogeneity complicates treatment decisio...
AIMS: This study investigates the role of macrophage histone lactylation-a protein modification-in atherosclerosis progression, particularly in peripheral artery disease (PAD), and evaluates the therapeutic potential of the herbal formula Ruan Jian Q...
Diabetes/metabolism research and reviews
Sep 1, 2025
AIMS: We aimed to explore the gut microbial and serum metabolic disturbances associated with the course of type 1 diabetes mellitus (T1DM), and identify potential biomarkers for discriminating T1DM from normoglycemia individuals by machine learning.
Journal of neuroradiology = Journal de neuroradiologie
Sep 1, 2025
INTRODUCTION: Early-onset Alzheimer's disease (EOAD) population is a clinically, genetically and pathologically heterogeneous condition. Identifying biomarkers related to disease progression is crucial for advancing clinical trials and improving ther...
BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS characterized by a heterogeneous disease trajectory, highlighting the need for biomarkers to predict disease activity. Current disease-monitorin...
Progressive lung fibrosis is frequently observed in patients with idiopathic interstitial pneumonias (IIPs), especially in those with idiopathic pulmonary fibrosis (IPF) being a representative form of IIPs characterized by a poor prognosis, even in t...
OBJECTIVES: The four-repeat (4R) tauopathies are a group of neurodegenerative diseases, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and globular glial tauopathy (GGT). This study aimed to characterize spatiotempor...
PURPOSE: To investigate the usefulness of a machine learning (ML) model that can predict the natural course of childhood myopia in evaluation of the inhibitory effects of 0.125% atropine on the progression of childhood myopia.
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