AIMC Topic: Disease Susceptibility

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Standard operating procedure for curation and clinical interpretation of variants in cancer.

Genome medicine Nov 29, 2019
Manually curated variant knowledgebases and their associated knowledge models are serving an increasingly important role in distributing and interpreting variants in cancer. These knowledgebases vary in their level of public accessibility, and the co...
Disease Susceptibility Humans Neoplasms Clinical Competence Models, Theoretical Knowledge Bases Disease Management Practice Patterns, Physicians'
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DeePathology: Deep Multi-Task Learning for Inferring Molecular Pathology from Cancer Transcriptome.

Scientific reports Nov 11, 2019
Despite great advances, molecular cancer pathology is often limited to the use of a small number of biomarkers rather than the whole transcriptome, partly due to computational challenges. Here, we introduce a novel architecture of Deep Neural Network...
Algorithms Reproducibility of Results Neoplasms Gene Expression Profiling Data Mining Humans Disease Susceptibility Neural Networks, Computer Organ Specificity Transcriptome Pathology, Molecular Deep Learning Computational Biology Gene Expression Regulation, Neoplastic
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Prediction of Potential Drug-Disease Associations through Deep Integration of Diversity and Projections of Various Drug Features.

International journal of molecular sciences Aug 22, 2019
Identifying new indications for existing drugs may reduce costs and expedites drug development. Drug-related disease predictions typically combined heterogeneous drug-related and disease-related data to derive the associations between drugs and disea...
Humans Algorithms Computational Biology Reproducibility of Results Pharmaceutical Preparations Deep Learning Drug-Related Side Effects and Adverse Reactions ROC Curve Disease Susceptibility
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Predicting lncRNA-disease associations using network topological similarity based on deep mining heterogeneous networks.

Mathematical biosciences Jul 16, 2019
A kind of noncoding RNA with length more than 200 nucleotides named long noncoding RNA (lncRNA) has gained considerable attention in recent decades. Many studies have confirmed that human genome contains many thousands of lncRNAs. LncRNAs play signif...
Humans Neoplasms Deep Learning Disease Susceptibility Beckwith-Wiedemann Syndrome Dementia Computational Biology MicroRNAs RNA, Long Noncoding
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Machine learning techniques for personalized breast cancer risk prediction: comparison with the BCRAT and BOADICEA models.

Breast cancer research : BCR Jun 20, 2019
BACKGROUND: Comprehensive breast cancer risk prediction models enable identifying and targeting women at high-risk, while reducing interventions in those at low-risk. Breast cancer risk prediction models used in clinical practice have low discriminat...
Disease Susceptibility Genetic Predisposition to Disease Models, Theoretical Population Surveillance Female Adult Breast Neoplasms Machine Learning Middle Aged Algorithms Risk Assessment Humans Precision Medicine Big Data Prognosis ROC Curve
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Dual Convolutional Neural Network Based Method for Predicting Disease-Related miRNAs.

International journal of molecular sciences Nov 23, 2018
Identification of disease-related microRNAs (disease miRNAs) is helpful for understanding and exploring the etiology and pathogenesis of diseases. Most of recent methods predict disease miRNAs by integrating the similarities and associations of miRNA...
MicroRNAs Disease Susceptibility Neural Networks, Computer Gene Regulatory Networks Algorithms Humans Reproducibility of Results Genetic Predisposition to Disease ROC Curve Genetic Association Studies Databases, Genetic
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Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Oct 25, 2018
OBJECTIVES: To evaluate the association of mannose-binding lectin (MBL) deficiency with susceptibility and clinical features of group B Streptococcus (GBS) causing meningitis in Chinese infants.
Mannose-Binding Lectin Middle Aged Meningitis, Bacterial China Risk Factors Infant Genotype Metabolism, Inborn Errors Young Adult Humans Case-Control Studies Genetic Association Studies Polymorphism, Genetic Adult Streptococcal Infections Female Alleles Male Infant, Newborn Streptococcus agalactiae Disease Susceptibility
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Enabling Precision Medicine through Integrative Network Models.

Journal of molecular biology Jul 9, 2018
A key challenge in precision medicine lies in understanding molecular-level underpinnings of complex human disease. Biological networks in multicellular organisms can generate hypotheses about disease genes, pathways, and their behavior in disease-re...
Humans Neural Networks, Computer Models, Biological Precision Medicine Disease Susceptibility Animals Species Specificity Genetic Predisposition to Disease
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Network-based association analysis to infer new disease-gene relationships using large-scale protein interactions.

PloS one Jun 27, 2018
Protein-protein interactions integrated with disease-gene associations represent important information for revealing protein functions under disease conditions to improve the prevention, diagnosis, and treatment of complex diseases. Although several ...
Protein Interaction Mapping Computational Biology Models, Biological Disease Susceptibility ROC Curve Protein Interaction Maps Genetic Predisposition to Disease Genetic Association Studies Neural Networks, Computer Algorithms Reproducibility of Results Gene Expression Profiling
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Patient Similarity Networks for Precision Medicine.

Journal of molecular biology Jun 1, 2018
Clinical research and practice in the 21st century is poised to be transformed by analysis of computable electronic medical records and population-level genome-scale patient profiles. Genomic data capture genetic and environmental state, providing in...
Precision Medicine Animals Genomics Models, Biological Disease Susceptibility Humans Neural Networks, Computer Machine Learning
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