AIMC Topic: Drug Delivery Systems
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Structural modification strategies for ferritin nanoparticles and their applications in biomedicine: a narrative review.
Nanoscale
Jul 31, 2025
Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...
Roadmap for Commercial Nanomedicine Development: Integrating Quality by Design Principles with Pharmaceutical Nanotechnology.
Molecular pharmaceutics
Jul 16, 2025
Integrating Quality by Design (QbD) principles into nanomedicine development marks a paradigm shift from traditional empirical approaches to more systematic risk-based strategies. This review explores the application of QbD in pharmaceutical nanotech...
Exploration of Predictive Potential of AI-enabled Portable System in Anticancer Drug Delivery: A Comparative Study with Modified Gompertz like Biphasic Response Model.
AAPS PharmSciTech
Jul 16, 2025
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
Picoeukaryote-based biohybrid microrobots for active delivery in the kidney.
Science advances
Jul 11, 2025
Confined spaces in the human body pose substantial challenges for biomedical procedures. Navigating these ultrasmall environments is essential for precise drug delivery, improving treatment outcomes and reducing adverse effects. Microrobots offer a p...
A formulation dataset of poly(lactide-co-glycolide) nanoparticles for small molecule delivery.
Scientific data
Jul 10, 2025
Poly(lactide-co-glycolide) (PLGA) nanoparticles are promising drug delivery systems, widely recognized for their ability to overcome various limitations associated with conventional formulations. However, designing and optimizing such formulations is...
Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier.
Journal of nanobiotechnology
Jul 8, 2025
The blood-brain barrier (BBB) poses a major challenge to the effective delivery of therapeutic agents for the treatment of central nervous system (CNS) disorders. The integration of cell membrane engineering with nanotechnology has recently enabled t...
Implementing partial least squares and machine learning regressive models for prediction of drug release in targeted drug delivery application.
Scientific reports
Jul 2, 2025
A combined methodology was performed based on chemometrics and machine learning regressive models in estimation of polysaccharide-coated colonic drug delivery. The release of medication was measured using Raman spectroscopy and the data was used for ...
Predicting PLGA nanoparticle size and zeta potential in synthesis for application of drug delivery via machine learning analysis.
Scientific reports
Jul 1, 2025
This study employed multiple machine learning (ML) methods to model and predict key attributes of PLGA nanoparticles, specifically particle size and zeta potential. The predictions were based on input variables, including PLGA polymer type, PLGA conc...
Self-assembling peptide hydrogels: design, mechanisms, characterization, and biomedical applications.
Soft matter
Jun 19, 2025
Self-assembled peptide hydrogels have emerged as a research frontier in biomedical engineering due to their exceptional water-retention capacity and spatiotemporal drug release kinetics. Researchers can fabricate biomaterials with customizable struct...
Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.
ACS nano
Jun 16, 2025
Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this work, utilizing anaerobic bacteria capable of seeking out hypoxic areas for flourishing, we constructed...
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