AIMC Topic: Drug Resistance, Multiple, Bacterial
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Multi-omics profiling of cross-resistance between ceftazidime-avibactam and meropenem identifies common and strain-specific mechanisms in clinical isolates.
mBio
Jun 4, 2025
is a highly versatile and resilient pathogen that can infect different tissues and rapidly develop resistance to multiple drugs. Ceftazidime-avibactam (CZA) is an antibiotic often used to treat multidrug-resistant infections; however, the knowledge ...
Predicting infections with multidrug-resistant organisms (MDROs) in neurocritical care patients with hospital-acquired pneumonia (HAP): development of a novel multivariate prediction model.
Microbiology spectrum
May 15, 2025
Hospital-acquired pneumonia (HAP) is prevalent in the neuro-intensive care unit (NICU), significantly increasing susceptibility to infections with multidrug-resistant organisms (MDROs), which result in high mortality rates and substantial healthcare ...
Antimicrobial resistance: Linking molecular mechanisms to public health impact.
SLAS discovery : advancing life sciences R & D
Apr 9, 2025
BACKGROUND: Antimicrobial resistance (AMR) develops into a worldwide health emergency through genetic and biochemical adaptations which enable microorganisms to resist antimicrobial treatment. β-lactamases (blaNDM, blaKPC) and efflux pumps (MexAB-Opr...
Machine learning prediction models for multidrug-resistant organism infections in ICU ventilator-associated pneumonia patients: Analysis using the MIMIC-IV database.
Computers in biology and medicine
Mar 27, 2025
OBJECTIVE: This study aims to construct and compare four machine learning models using the MIMIC-IV database to identify high-risk factors for multidrug-resistant organism (MDRO) infection in Ventilator-associated pneumonia (VAP) patients.
Enhanced diagnosis of multi-drug-resistant microbes using group association modeling and machine learning.
Nature communications
Mar 25, 2025
New solutions are needed to detect genotype-phenotype associations involved in microbial drug resistance. Herein, we describe a Group Association Model (GAM) that accurately identifies genetic variants linked to drug resistance and mitigates false-po...
Assessment for antibiotic resistance in : A practical and interpretable machine learning model based on genome-wide genetic variation.
Virulence
Mar 21, 2025
() antibiotic resistance poses a global health threat. Accurate identification of antibiotic resistant strains is essential for the control of infection. In the present study, our goal is to leverage the whole-genome data of to develop practical an...
Antibacterial and antibiofilm activities of star anise-cinnamon essential oil against multidrug-resistant Thompson.
Frontiers in cellular and infection microbiology
Mar 3, 2025
INTRODUCTION: The emergence of foodborne multidrug-resistant (MDR) has attracted considerable global attention. Given that food is the primary transmission route, our study focuses on , a freshwater snail that is commonly consumed as a specialty foo...
Explainable deep learning and virtual evolution identifies antimicrobial peptides with activity against multidrug-resistant human pathogens.
Nature microbiology
Jan 17, 2025
Artificial intelligence (AI) is a promising approach to identify new antimicrobial compounds in diverse microbial species. Here we developed an AI-based, explainable deep learning model, EvoGradient, that predicts the potency of antimicrobial peptide...
Developing and validating a machine learning model to predict multidrug-resistant -related septic shock.
Frontiers in immunology
Jan 10, 2025
BACKGROUND: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) infections pose a significant global healthcare challenge, particularly due to the high mortality risk associated with septic shock. This study aimed to develop and validate a machine lea...
Phenotypic antibiotic resistance prediction using antibiotic resistance genes and machine learning models in Mannheimia haemolytica.
Veterinary microbiology
Jan 8, 2025
Mannheimia haemolytica is one of the most common causative agents of bovine respiratory disease (BRD); however, antibiotic resistance in this species is increasing, making treatment more difficult. Integrative-conjugative elements (ICE), a subset of ...
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