Phytomedicine : international journal of phytotherapy and phytopharmacology
Sep 15, 2025
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder with increasing global prevalence. Chaihu-shugan-san (CSS) is a Chinese medicine compound with reported neuroprotective properties. However, the precise bioactive consti...
RESEARCH PURPOSE: This study proposes MMFi-DPBML, a deep learning framework that in-tegrates multi-molecular fingerprint features for predicting ingredient-target interactions (ITIs) in traditional Chinese medicine (TCM). By capturing di-verse struct...
Journal of pharmaceutical and biomedical analysis
Aug 7, 2025
Curcumae Rhizoma (Ezhu) is a multi-species herbal medicine with excellent medicinal value and development potential. However, challenges such as the difficulty in differentiating its varieties and the limitations of current methods for determining mi...
Pholiota adiposa is recognized for its health benefits, particularly in Alzheimer's disease (AD), but its molecular mechanism remains elusive. Our study employs network pharmacology and machine learning to uncover its therapeutic potential. We constr...
BACKGROUND: Several clinical cases and experiments have demonstrated the effectiveness of traditional Chinese medicine (TCM) formulas in treating and preventing diseases. These formulas contain critical information about their ingredients, efficacy, ...
ETHNOPHARMACOLOGICAL RELEVANCE: Erzhi Pill (EZP), a traditional Chinese medicine used for various cancers, exhibits antitumor potential, though its role and mechanisms in Triple-Negative Breast Cancer (TNBC) remain unclear.
Journal of pharmaceutical and biomedical analysis
Jul 6, 2025
Ginger-processed Eucommiae Cortex (G-EC) is a traditional herbal preparation with a long history of clinical application. However, the lack of quantitative standards, undefined chemical transformation pathways, and unidentified quality markers (Q-mar...
ETHNOPHARMACOLOGICAL RELEVANCE: Angong Niuhuang Pills (AGNHP), a famous Chinese medicine compound preparation, is widely used to treat stroke and other brain disorders. However, owing to the complexity of herbal components and diversity of production...
Predicting drug-drug interactions (DDI) is crucial for preventing adverse reactions in patients and plays a vital role in drug design and development. However, traditional Chinese medicine (TCM) formulations, typically composed of multiple herbal ing...
Given the morphological similarity and medicinal efficacy differences between Acorus tatarinowii Rhizoma and Acorus calamus Rhizoma, both belonging to the Acorus rhizome slices, as well as the phenomenon of their mixed use in the market, this study a...
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