AIMC Topic: ErbB Receptors

Clear Filters Showing 1 to 10 of 82 articles

Improving Covalent and Noncovalent Molecule Generation via Reinforcement Learning with Functional Fragments.

Journal of chemical information and modeling Jun 5, 2025
Small-molecule drugs play a critical role in cancer therapy by selectively targeting key signaling pathways that drive tumor growth. While deep learning models have advanced drug discovery, there remains a lack of generative frameworks for covalent ...
Humans Molecular Docking Simulation ErbB Receptors Protein Kinase Inhibitors Agammaglobulinaemia Tyrosine Kinase Small Molecule Libraries Drug Design Deep Learning Molecular Dynamics Simulation Ligands
View on PubMed DOI

Exploring Hidden Dangers: Predicting Mycotoxin-like Toxicity and Mapping Toxicological Networks in Hepatocellular Carcinoma.

Journal of chemical information and modeling May 20, 2025
Mycotoxins are potent triggers of hepatocellular carcinoma (HCC) due to their intricate interplay with cellular macromolecules and signaling pathways. This study integrates machine learning and biomolecular analyses to elucidate the mechanisms underl...
Humans Machine Learning Molecular Docking Simulation Liver Neoplasms ErbB Receptors Carcinoma, Hepatocellular Protein Interaction Maps Signal Transduction Mycotoxins
View on PubMed DOI

Machine learning in prediction of epidermal growth factor receptor status in non-small cell lung cancer brain metastases: a systematic review and meta-analysis.

BMC cancer May 1, 2025
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are present in 10-60% of all non-small cell lung cancer (NSCLC) patients and are associated with dismal prognosis. Lung cancer brain metastases (LCBM) are a common complication of lung can...
Machine Learning Prognosis Humans Brain Neoplasms Lung Neoplasms Carcinoma, Non-Small-Cell Lung Mutation ErbB Receptors
View on PubMed DOI

Predicting Gene Comutation of EGFR and TP53 by Radiomics and Deep Learning in Patients With Lung Adenocarcinomas.

Journal of thoracic imaging May 1, 2025
PURPOSE: This study was designed to construct progressive binary classification models based on radiomics and deep learning to predict the presence of epidermal growth factor receptor ( EGFR ) and TP53 mutations and to assess the models' capacities t...
Tumor Suppressor Protein p53 ErbB Receptors Adenocarcinoma of Lung Radiomics Male Middle Aged Lung Deep Learning Lung Neoplasms Mutation Reproducibility of Results Aged Adult Sensitivity and Specificity Retrospective Studies Tomography, X-Ray Computed Female Humans
View on PubMed DOI

Deep learning radiopathomics predicts targeted therapy sensitivity in EGFR-mutant lung adenocarcinoma.

Journal of translational medicine Apr 29, 2025
BACKGROUND: Ttyrosine kinase inhibitors (TKIs) represent the standard first-line treatment for patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma. However, not all patients with EGFR mutations respond to TKIs. This study...
ErbB Receptors Protein Kinase Inhibitors Adenocarcinoma of Lung Deep Learning Lung Neoplasms Mutation Molecular Targeted Therapy Aged Male Middle Aged Humans Retrospective Studies Tomography, X-Ray Computed Female
View on PubMed DOI

Identifying potential risk genes for clear cell renal cell carcinoma with deep reinforcement learning.

Nature communications Apr 15, 2025
Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of renal cell carcinoma. However, our understanding of ccRCC risk genes remains limited. This gap in knowledge poses challenges to the effective diagnosis and treatment of ccRCC. To a...
Humans Risk Factors Deep Learning Genetic Predisposition to Disease ErbB Receptors Computational Biology Carcinoma, Renal Cell Markov Chains Reinforcement Machine Learning Kidney Neoplasms
View on PubMed DOI

Exploring 4 generation EGFR inhibitors: A review of clinical outcomes and structural binding insights.

European journal of pharmacology Apr 9, 2025
Epidermal growth factor receptor (EGFR) is a potential target for anticancer therapies and plays a crucial role in cell growth, survival, and metastasis. EGFR gene mutations trigger aberrant signaling, leading to non-small cell lung cancer (NSCLC). T...
Humans ErbB Receptors Animals Protein Kinase Inhibitors Antineoplastic Agents Carcinoma, Non-Small-Cell Lung Structure-Activity Relationship Lung Neoplasms Mutation
View on PubMed DOI

Predictive models of epidermal growth factor receptor mutation in lung adenocarcinoma using PET/CT-based radiomics features.

Medical physics Apr 1, 2025
BACKGROUND: Lung adenocarcinoma (LAC) comprises a substantial subset of non-small cell lung cancer (NSCLC) diagnoses, where epidermal growth factor receptor (EGFR) mutations play a pivotal role as indicators for therapeutic intervention with targeted...
Humans Retrospective Studies Female Middle Aged Mutation Image Processing, Computer-Assisted ErbB Receptors Lung Neoplasms Aged Adenocarcinoma of Lung Positron Emission Tomography Computed Tomography Radiomics Male
View on PubMed DOI

Predicting a failure of postoperative thromboprophylaxis in non-small cell lung cancer: A stacking machine learning approach.

PloS one Apr 1, 2025
BACKGROUND: Non-small-cell lung cancer (NSCLC) and its surgery significantly increase the venous thromboembolism (VTE) risk. This study explored the VTE risk factors and established a machine-learning model to predict a failure of postoperative throm...
Middle Aged Female Lung Neoplasms Humans Postoperative Complications Risk Factors Machine Learning Carcinoma, Non-Small-Cell Lung ROC Curve Aged Retrospective Studies Venous Thromboembolism Male ErbB Receptors
View on PubMed DOI

Ontology-driven identification of inconsistencies in clinical data: A case study in lung cancer phenotyping.

Journal of biomedical informatics Mar 21, 2025
OBJECTIVE: To illustrate the use of an ontology in evaluating data quality in the medical field, focusing on phenotyping lung cancers.
Mutation Data Accuracy Biological Ontologies ErbB Receptors Protein Kinase Inhibitors Humans Data Warehousing Phenotype Anaplastic Lymphoma Kinase Lung Neoplasms
View on PubMed DOI
Popular Topics
Recent Journals