AIMC Topic: Gene Expression Profiling
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Fuzzy-Rough Entropy Measure and Histogram Based Patient Selection for miRNA Ranking in Cancer.
IEEE/ACM transactions on computational biology and bioinformatics
Nov 1, 2016
MicroRNAs (miRNAs) are known as an important indicator of cancers. The presence of cancer can be detected by identifying the responsible miRNAs. A fuzzy-rough entropy measure (FREM) is developed which can rank the miRNAs and thereby identify the rele...
A support vector machine model provides an accurate transcript-level-based diagnostic for major depressive disorder.
Translational psychiatry
Oct 25, 2016
Major depressive disorder (MDD) is a critical cause of morbidity and disability with an economic cost of hundreds of billions of dollars each year, necessitating more effective treatment strategies and novel approaches to translational research. A no...
Integrating network, sequence and functional features using machine learning approaches towards identification of novel Alzheimer genes.
BMC genomics
Oct 18, 2016
BACKGROUND: Alzheimer's disease (AD) is a complex progressive neurodegenerative disorder commonly characterized by short term memory loss. Presently no effective therapeutic treatments exist that can completely cure this disease. The cause of Alzheim...
Transcriptomic alterations in Sitophilus zeamais in response to allyl isothiocyanate fumigation.
Pesticide biochemistry and physiology
Oct 11, 2016
To study the fumigation mechanisms of Allyl isothiocyanate (AITC) a promising biorational alternative to present fumigants (phosphine and methyl bromide), and provide theoretical basis for its further development in the control of stored grain pests,...
Inferring Unknown Biological Function by Integration of GO Annotations and Gene Expression Data.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2016
Characterizing genes with semantic information is an important process regarding the description of gene products. In spite that complete genomes of many organisms have been already sequenced, the biological functions of all of their genes are still ...
Symbiont modulates expression of specific gene categories in Angomonas deanei.
Memorias do Instituto Oswaldo Cruz
Oct 3, 2016
Trypanosomatids are parasites that cause disease in humans, animals, and plants. Most are non-pathogenic and some harbor a symbiotic bacterium. Endosymbiosis is part of the evolutionary process of vital cell functions such as respiration and photosyn...
Improving information retrieval in functional analysis.
Computers in biology and medicine
Sep 24, 2016
Transcriptome analysis is essential to understand the mechanisms regulating key biological processes and functions. The first step usually consists of identifying candidate genes; to find out which pathways are affected by those genes, however, funct...
Tissue enrichment analysis for C. elegans genomics.
BMC bioinformatics
Sep 13, 2016
BACKGROUND: Over the last ten years, there has been explosive development in methods for measuring gene expression. These methods can identify thousands of genes altered between conditions, but understanding these datasets and forming hypotheses base...
Identification of informative genes and pathways using an improved penalized support vector machine with a weighting scheme.
Computers in biology and medicine
Aug 4, 2016
Incorporation of pathway knowledge into microarray analysis has brought better biological interpretation of the analysis outcome. However, most pathway data are manually curated without specific biological context. Non-informative genes could be incl...
An approach for deciphering patient-specific variations with application to breast cancer molecular expression profiles.
Journal of biomedical informatics
Jul 28, 2016
Several studies have successfully used molecular expression profiling in conjunction with classification techniques for discerning distinct disease groups. However, a majority of these studies do not provide sufficient insights into potential patient...
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