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Gold

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A new approach to dilution prediction of underground mine gold using computing techniques.

Anais da Academia Brasileira de Ciencias
Controlling ore dilution in underground mining is challenging. In this study, data from a Brazilian gold mine were analyzed, covering 70 chambers and 26 variables. Six key variables were identified through decision tree analysis, forming the basis of...

Artificial intelligence enhanced microfluidic system for multiplexed point-of-care-testing of biological thiols.

Talanta
Cysteamine (CA) serves as a cystine-depleting agent employed in the management of cystinosis and a range of other medical conditions. Monitoring blood CA levels at the point of care is imperative due to the risk of toxicity associated with elevated C...

A machine-learning-integrated portable electrochemiluminescence sensing platform for the visualization and high-throughput immunoassays.

Talanta
Electrochemiluminescence (ECL)-based point-of-care testing (POCT) has the potential to facilitate the rapid identification of diseases, offering advantages such as high sensitivity, strong selectivity, and minimal background interference. However, as...

Neuro-computational simulation of blood flow loaded with gold and maghemite nanoparticles inside an electromagnetic microchannel under rapid and unexpected change in pressure gradient.

Electromagnetic biology and medicine
In cardiovascular research, electromagnetic fields generated by Riga plates are utilized to study or manipulate blood flow dynamics, which is particularly crucial in developing treatments for conditions such as arterial plaque deposition and understa...

Ultrasensitive Detection of Circulating Plasma Cells Using Surface-Enhanced Raman Spectroscopy and Machine Learning for Multiple Myeloma Monitoring.

Analytical chemistry
Multiple myeloma is a hematologic malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Despite therapeutic advancements, there remains a critical need for reliable, noninvasive methods to monitor multiple myeloma...

Rapid and Differential Diagnosis of Sepsis Stages Using an Advanced 3D Plasmonic Bimetallic Alloy Nanoarchitecture-Based SERS Biosensor Combined with Machine Learning for Multiple Analyte Identification.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Rapid and accurate differential diagnosis of infections, sepsis, and septic shock is essential for preventing unnecessary antibiotic overuse and improving the chance of patient survival. To address this, a 3D gold nanogranule decorated gold-silver al...

Dual-Mode Colorimetric/SERS Lateral Flow Immunoassay with Machine Learning-Driven Optimization for Ultrasensitive Mycotoxin Detection.

Analytical chemistry
Detecting and quantifying mycotoxins using LFIA are challenging due to the need for high sensitivity and accuracy. To address this, a dual-mode colorimetric-SERS LFIA was developed for detecting deoxynivalenol (DON). Rhodium nanocores provided strong...

SERS based determination of ceftriaxone, ampicillin, and vancomycin in serum using WS/Au@Ag nanocomposites and a 2D-CNN regression model.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Accurate therapeutic drug monitoring (TDM) of antibiotics including ceftriaxone, ampicillin, and vancomycin plays an important role in the treatment of neonatal sepsis, a common and life-threatening disease in neonates. A highly sensitive surface-enh...

Highly Sensitive and Interference-Free Detection of Multiple Drug Molecules in Serum Using Dual-Modified SERS Substrates Combined with AI Algorithm Analysis.

Analytical chemistry
Surface-enhanced Raman spectroscopy (SERS) technology has shown broad potential in drug concentration detection, but its application in blood drug monitoring faces significant challenges. The primary difficulty lies in overcoming the interference cau...

Fluorescent sensor array for rapid bacterial identification using antimicrobial peptide-functionalized gold nanoclusters and machine learning.

Talanta
Bacterial infectious diseases pose significant challenges to public health, emphasizing the need for rapid and accurate diagnostic tools. Here, we introduced a multichannel fluorescent sensor array based on antimicrobial peptide-functionalized gold n...