AIMC Topic: HCT116 Cells
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Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale.
Nature communications
Sep 13, 2021
Mass spectrometry (MS)-based ubiquitinomics provides system-level understanding of ubiquitin signaling. Here we present a scalable workflow for deep and precise in vivo ubiquitinome profiling, coupling an improved sample preparation protocol with dat...
sgRNACNN: identifying sgRNA on-target activity in four crops using ensembles of convolutional neural networks.
Plant molecular biology
Jan 1, 2021
We proposed an ensemble convolutional neural network model to identify sgRNA high on-target activity in four crops and we used one-hot encoding and k-mers for sequence encoding. As an important component of the CRISPR/Cas9 system, single-guide RNA (s...
Synthesis and biological characterization of MnZnEuDyFeO nanoparticles by sonochemical approach.
Materials science & engineering. C, Materials for biological applications
Dec 6, 2019
Metallic nanoparticles (NPs) possess unique properties which makes them attractive candidates for various applications especially in field of experimental medicine and drug delivery. Many approaches were developed to synthesize divers and customized ...
Automating Complex, Multistep Processes on a Single Robotic Platform to Generate Reproducible Phosphoproteomic Data.
SLAS discovery : advancing life sciences R & D
Sep 26, 2019
Mass spectrometry-based phosphoproteomics holds promise for advancing drug treatment and disease diagnosis; however, its clinical translation has thus far been limited. This is in part due to an unstandardized and segmented sample preparation process...
Towards early monitoring of chemotherapy-induced drug resistance based on single cell metabolomics: Combining single-probe mass spectrometry with machine learning.
Analytica chimica acta
Sep 25, 2019
Despite the presence of methods evaluating drug resistance during chemotherapies, techniques, which allow for monitoring the degree of drug resistance in early chemotherapeutic stage from single cells in their native microenvironment, are still absen...
Anticancer Drug Affects Metabolomic Profiles in Multicellular Spheroids: Studies Using Mass Spectrometry Imaging Combined with Machine Learning.
Analytical chemistry
Apr 15, 2019
Multicellular spheroids (hereinafter referred to as spheroids) are 3D biological models. The metabolomic profiles inside spheroids provide crucial information reflecting the molecular phenotypes and microenvironment of cells. To study the influence o...
3D Fabrication of Fully Iron Magnetic Microrobots.
Small (Weinheim an der Bergstrasse, Germany)
Mar 4, 2019
Biocompatibility and high responsiveness to magnetic fields are fundamental requisites to translate magnetic small-scale robots into clinical applications. The magnetic element iron exhibits the highest saturation magnetization and magnetic susceptib...
Synthesis of chitosan nanoparticles, chitosan-bulk, chitosan nanoparticles conjugated with glutaraldehyde with strong anti-cancer proliferative capabilities.
Artificial cells, nanomedicine, and biotechnology
Jan 31, 2019
In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, we have investigated the effect of chitosan-bulk (Ch-bulk), chitosan nanoparticles (ChNP), chitosan ...
Predictable and precise template-free CRISPR editing of pathogenic variants.
Nature
Nov 7, 2018
Following Cas9 cleavage, DNA repair without a donor template is generally considered stochastic, heterogeneous and impractical beyond gene disruption. Here, we show that template-free Cas9 editing is predictable and capable of precise repair to a pre...
Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.
Clinical pharmacology and therapeutics
Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Mutation, Missense
Dihydrouracil Dehydrogenase (NADP)
Pharmacogenomic Testing
Computer Simulation
Pharmacogenomic Variants
Risk Assessment
HEK293 Cells
Humans
Models, Molecular
Pharmacogenetics
Dose-Response Relationship, Drug
Gene Frequency
Machine Learning
Fluorouracil
Genotype
Protein Conformation
Cell Survival
Inhibitory Concentration 50
Antimetabolites, Antineoplastic
Predictive Value of Tests
HCT116 Cells
Structure-Activity Relationship
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