AIMC Topic: Host-Pathogen Interactions
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Editorial: Exploring genetic characteristics and molecular mechanisms of host adaptation of viruses with artificial intelligence (AI) or (and) biological (BIO) approaches.
Frontiers in cellular and infection microbiology
Aug 26, 2024
Significance of Artificial Intelligence in the Study of Virus-Host Cell Interactions.
Biomolecules
Jul 26, 2024
A highly critical event in a virus's life cycle is successfully entering a given host. This process begins when a viral glycoprotein interacts with a target cell receptor, which provides the molecular basis for target virus-host cell interactions for...
Deep learning for protein complex structure prediction.
Current opinion in structural biology
Jan 31, 2023
Recent developments in the structure prediction of protein complexes have resulted in accuracies rivalling experimental methods in many cases. The high accuracy is mainly observed in dimeric complexes and other problems such as protein disorder and p...
Deep learning based protocol to construct an immune-related gene network of host-pathogen interactions in plants.
STAR protocols
Dec 14, 2022
Investigating network behavior from host-pathogen interactions is challenging. Here, we present the deep-learning-based protocol to construct an immune-related gene network and list the genes involved in the defense response of host to specific bioti...
New feature extraction from phylogenetic profiles improved the performance of pathogen-host interactions.
Frontiers in cellular and infection microbiology
Aug 2, 2022
MOTIVATION: The understanding of pathogen-host interactions (PHIs) is essential and challenging research because this potentially provides the mechanism of molecular interactions between different organisms. The experimental exploration of PHI is tim...
Accurate diagnosis of atopic dermatitis by combining transcriptome and microbiota data with supervised machine learning.
Scientific reports
Jan 7, 2022
Atopic dermatitis (AD) is a common skin disease in childhood whose diagnosis requires expertise in dermatology. Recent studies have indicated that host genes-microbial interactions in the gut contribute to human diseases including AD. We sought to de...
Genes and regulatory mechanisms associated with experimentally-induced bovine respiratory disease identified using supervised machine learning methodology.
Scientific reports
Nov 25, 2021
Bovine respiratory disease (BRD) is a multifactorial disease involving complex host immune interactions shaped by pathogenic agents and environmental factors. Advancements in RNA sequencing and associated analytical methods are improving our understa...
Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response.
Frontiers in immunology
Oct 29, 2021
Vaccination to prevent infectious disease is one of the most successful public health interventions ever developed. And yet, variability in individual vaccine effectiveness suggests that a better mechanistic understanding of vaccine-induced immune re...
Host-Pathogen Interactions
Canonical Correlation Analysis
Vaccine Efficacy
Middle Aged
Hepatitis B Vaccines
Gene Expression Profiling
Hepatitis B Antibodies
Aged
Dendritic Cells
High-Throughput Nucleotide Sequencing
Adult
Hepatitis B
Male
Humans
Single-Cell Analysis
Machine Learning
Vaccination
Female
DMFMDA: Prediction of Microbe-Disease Associations Based on Deep Matrix Factorization Using Bayesian Personalized Ranking.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2021
Identifying the microbe-disease associations is conducive to understanding the pathogenesis of disease from the perspective of microbe. In this paper, we propose a deep matrix factorization prediction model (DMFMDA) based on deep neural network. Firs...
Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected With Through Co-Expression and Machine Learning.
Frontiers in immunology
Jul 8, 2021
is a major pathogen that causes a high mortality rate in trout farms. However, systemic responses to the pathogen and its interactions with multiple organs during the course of infection have not been well described. In this study, dual-organ transc...
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