Journal of chemical information and modeling
Nov 18, 2025
Neuroscience is the most difficult therapeutic area for pharmaceutical drug discovery. The blood-brain barrier (BBB) prevents ∼100% of large molecules and >98% of small molecules from penetrating the central nervous system (CNS). Most small molecule ...
Journal of chemical information and modeling
Nov 18, 2025
The design of novel molecules underpins advances in both drug discovery and biomaterials engineering. Traditional approaches, from natural product isolation to high-throughput screening, have delivered important therapeutics but remain costly, ineffi...
Journal of chemical information and modeling
Nov 18, 2025
Chemical allergens are prevalent in both consumer and industrial products, often triggering hypersensitivity reactions with significant public health and regulatory implications. Traditional experimental screening is time-consuming and labor-intensiv...
Sjögren's disease is often an underdiagnosed autoimmune condition that primarily affects the exocrine glands, resulting in symptoms such as dry eyes and dry mouth. Diagnostic challenges stem from nonspecific symptoms, the absence of definitive biomar...
Phosphodiesterase 4 (PDE4) has been validated as a promising therapeutic target for idiopathic pulmonary fibrosis (IPF), a devastating interstitial lung disease lacking really effective therapeutic drugs, particularly exacerbated in the post-COVID-19...
Journal of public health management and practice : JPHMP
Nov 18, 2025
CONTEXT: High turnover rates in the public health workforce pose ongoing challenges to maintain essential services and institutional knowledge. Recent studies indicate that job dissatisfaction, burnout, and structural barriers have intensified follow...
OBJECTIVES: It remains debated whether gestational hypertension (GH) and pre-eclampsia (PE) are distinct entities or different spectra of the same disease. Currently, comparative studies of risk factors for GH and PE in the same population are limite...
BACKGROUND: HPV status is a key determinant of prognosis and treatment response in head and neck squamous cell carcinoma (HNSCC). To investigate how HPV influences the tumor-immune-stromal landscape, we performed high-dimensional spatial profiling, i...
Journal of neuroengineering and rehabilitation
Nov 18, 2025
Physical fatigue significantly contributes to work-related musculoskeletal disorders, highlighting the need to understand its effects during manual handling tasks for effective prevention strategies. This study examines the correlation between change...
Antimicrobial resistance and infection control
Nov 18, 2025
BACKGROUND: The transmission of antibiotic-resistant bacteria in intensive care units (ICUs) poses a significant challenge to infection control and patient safety. While direct patient-to-patient transmission is well documented, the relative contribu...
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