BACKGROUND: Mental health challenges are prevalent among Canadian higher education students, with significant rates of depression and anxiety often going untreated due to reduced early detection, stigmatizing beliefs, and practical barriers. The U-Fl...
In the context of global economic austerity in the post epidemic era, housing, as one of the basic human needs, has become particularly important for accurate prediction of house prices. BP neural network is widely used in prediction tasks, but their...
BACKGROUND: Renal dysfunction is a frequent and clinically relevant complication of cirrhosis, yet chronic kidney disease (CKD) often remains underrecognized, particularly in non-acute settings. Early identification of at-risk patients is essential t...
BACKGROUND: Depression is a psychological disorder characterized by altered self-referential cognition and impaired emotional expression. Traditional diagnostic methods can be costly or intrusive, while Speech-based analysis offers an accessible alte...
The quality of strong-flavor Baijiu (SFB) is directly determined by key flavor compounds, which are influenced by microorganisms during fermentation. This study employed flavoromics and machine learning technologies to explore the relationship betwee...
Targeting therapeutic nanoparticles to the brain poses a challenge due to the restrictive nature of the blood-brain barrier (BBB). Here we report the development of mRNA-loaded lipid nanoparticles (LNPs) functionalized with BBB-interacting small mole...
Biochemical and biophysical research communications
Sep 16, 2025
CircRNAs are ubiquitously expressed across diverse tissues and cells, playing a pivotal role not only in protein-mediated biological processes but also in disease prevention and therapeutics. RNA-RBP interactions are critical for deciphering gene reg...
While the neural underpinnings of semantic cognition have been extensively studied, the brain mechanisms that allow the extraction of meaning from the initially perceptual visual linguistic input are less understood. These mechanisms have typically b...
Journal of chemical theory and computation
Sep 16, 2025
Biased allosteric modulators (BAMs) offer a promising avenue for developing safer and more selective therapeutics for G protein-coupled receptors (GPCRs). However, their molecular mechanisms remain unclear due to the complex combination of biased and...
Journal of chemical information and modeling
Sep 16, 2025
Combination therapy presents a transformative approach to treating complex diseases such as cancer by mitigating toxicity and resistance challenges inherent to monotherapy. A critical gap in current computational methods, however, lies in their inabi...
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