AIMC Topic: Humans

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Nonparametric machine learning for precision medicine with longitudinal clinical trials and Bayesian additive regression trees with mixed models.

Statistics in medicine
Precision medicine is an active area of research that could offer an analytic paradigm shift for clinical trials and the subsequent treatment decisions based on them. Clinical trials are typically analyzed with the intent of discovering beneficial tr...

Attenuation correction using deep learning for brain perfusion SPECT images.

Annals of nuclear medicine
OBJECTIVE: Non-uniform attenuation correction using computed tomography (CT) improves the image quality and quantification of single-photon emission computed tomography (SPECT). However, it is not widely used because it requires a SPECT/CT scanner. T...

Reservoir hosts prediction for COVID-19 by hybrid transfer learning model.

Journal of biomedical informatics
The recent outbreak of COVID-19 has infected millions of people around the world, which is leading to the global emergency. In the event of the virus outbreak, it is crucial to get the carriers of the virus timely and precisely, then the animal origi...

Virtual EEG-electrodes: Convolutional neural networks as a method for upsampling or restoring channels.

Journal of neuroscience methods
BACKGROUND: In clinical practice, EEGs are assessed visually. For practical reasons, recordings often need to be performed with a reduced number of electrodes and artifacts make assessment difficult. To circumvent these obstacles, different interpola...

Generative Adversarial Networks to Synthesize Missing T1 and FLAIR MRI Sequences for Use in a Multisequence Brain Tumor Segmentation Model.

Radiology
Background Missing MRI sequences represent an obstacle in the development and use of deep learning (DL) models that require multiple inputs. Purpose To determine if synthesizing brain MRI scans using generative adversarial networks (GANs) allows for ...

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution.

Biochemical and biophysical research communications
Free fatty acid receptor 1 (FFAR1 or GPR40) has attracted attention for the treatment of type 2 diabetes mellitus, and various small-molecule agonists have been developed. However, most FFAR1 agonists as well as endogenous ligands, such as linoleic a...

Predicting opioid overdose risk of patients with opioid prescriptions using electronic health records based on temporal deep learning.

Journal of biomedical informatics
The US is experiencing an opioid epidemic, and opioid overdose is causing more than 100 deaths per day. Early identification of patients at high risk of Opioid Overdose (OD) can help to make targeted preventative interventions. We aim to build a deep...

Explainable automated coding of clinical notes using hierarchical label-wise attention networks and label embedding initialisation.

Journal of biomedical informatics
BACKGROUND: Diagnostic or procedural coding of clinical notes aims to derive a coded summary of disease-related information about patients. Such coding is usually done manually in hospitals but could potentially be automated to improve the efficiency...

A new approach to medical diagnostic decision support.

Journal of biomedical informatics
Data mining is a powerful tool to reduce costs and mitigate errors in the diagnostic analysis and repair of complex engineered system, but it has yet to be applied systematically to the most complex and socially expensive system - the human body. The...