Proceedings of the National Academy of Sciences of the United States of America
Dec 10, 2025
DNA methylation is a conserved epigenetic modification essential for maintaining genome stability. However, how methyltransferases maintain CG methylation within compact chromatin, including centromeres, remains unclear. In humans, CDCA7 is necessary...
Cortisol is known to promote memory for emotionally arousing experiences, yet the neural networks involved in enhancing these memories are unknown. Here, we combine pharmacological fMRI with an analysis approach to determine the dynamic brain network...
Classification constitutes a fundamental cognitive challenge for both biological and artificial intelligence systems. Here, we investigated how the brain categorizes stimuli that are not linearly separable in the physical world by analyzing the geome...
Naturalistic scenes are of key interest for visual perception, but controlling their perceptual and semantic properties is challenging. Previous work on naturalistic scenes has frequently focused on collections of discrete images with considerable ph...
Traditional survival predictions for oral squamous cell carcinoma (OSCC) rely on TNM staging, which lacks individualized prognostic value. Clinical factors such as performance status, age, sex, and lifestyle affect outcomes but are underrepresented i...
This paper introduces the Gray Wolf Optimized Convolutional Transformer Network, a combined deep learning framework aimed at accurately and efficiently recognizing dynamic hand gestures, especially in American Sign Language (ASL). The model integrate...
Migraine is a complex neurological disorder with substantial heritability, yet genome-wide association studies (GWAS) have explained only a fraction of its genetic component. We developed InsightGWAS, a Transformer-based model, to enhance genetic dis...
INTRODUCTION: Prescribing high-dose antipsychotics is typically reserved for individuals with treatment-resistant severe mental illnesses, such as schizophrenia, bipolar disorder and psychotic depression. It carries an increased risk of adverse drug ...
OBJECTIVES: There is limited research exploring the age-related difference in communication when describing pain experiences. This project aimed to identify key differences between adolescents', young adults' and adults' (i) preferred communication m...
BACKGROUND: Google Street View (GSV) images offer a unique and scalable alternative to in-person audits for examining neighborhood built environment characteristics. Additionally, most prior neighborhood studies have relied on cross-sectional designs...
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