OBJECTIVE: Metformin is the preferred first-line medication for management of type 2 diabetes and prediabetes. However, over a third of patients experience primary or secondary therapeutic failure. We developed machine learning models to predict whic...
Journal of chemical information and modeling
Oct 16, 2018
Machine learning has shown enormous potential for computer-aided drug discovery. Here we show how modern convolutional neural networks (CNNs) can be applied to structure-based virtual screening. We have coupled our densely connected CNN (DenseNet) wi...
Prostate cancer (PC) is more common cancer in older men. Then, the existing evaluation method of PC risk grades is based on the AJCC (American Joint Committee on Cancer) staging/scoring system. It utilizes the comprehensive risk data of the prostate-...
While the interaction between a needle and the surrounding tissue is known to cause a significant targeting error in prostate biopsy leading to false-negative results, few studies have demonstrated how it impacts in the actual procedure. We performed...
BACKGROUND AND OBJECTIVE: Efficiently capturing the severity of positive valence symptoms could aid in risk stratification for adverse outcomes among patients with psychiatric disorders and identify optimal treatment strategies for patient subgroups....
The field of nanomedicine has made substantial strides in the areas of therapeutic and diagnostic development. For example, nanoparticle-modified drug compounds and imaging agents have resulted in markedly enhanced treatment outcomes and contrast eff...
Journal of the American College of Radiology : JACR
Oct 15, 2018
OBJECTIVES: With much hype about artificial intelligence (AI) rendering radiologists redundant, a simple radiologist-augmented AIÂ workflow is evaluated; the premise is that inclusion of a radiologist's opinion into an AI algorithm would make the algo...
BACKGROUND: Automatic sleep stage classification is essential for long-term sleep monitoring. Wearable devices show more advantages than polysomnography for home use. In this paper, we propose a novel method for sleep staging using heart rate and wri...
The detection of Adverse Medical Events (AMEs) plays an important role in disease management in ensuring efficient treatment delivery and quality improvement of health services. Recently, with the rapid development of hospital information systems, a ...
Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing
Oct 15, 2018
BACKGROUND AND PURPOSE: With the growth in the aging population, and shortage of primary care providers, telehealth programs are needed to optimize healthy independent living for older adults. The purpose of this study was to evaluate a nurse-led int...
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