Proceedings of the National Academy of Sciences of the United States of America
Jun 12, 2025
The relationship between genotype and phenotype remains an outstanding question for organism-level traits because these traits are generally . The challenge arises from complex traits being determined by a combination of multiple genes (or loci), whi...
BACKGROUND: Large language models (LLMs) offer significant potential to streamline research workflows and enhance productivity. However, limited data exist on the extent of their adoption within the mental health research community.
BACKGROUND: Accumulating evidence suggests that migraine patients present abnormal brain responses to salient sensory and emotional stimuli. However, it is still unclear whether this is a generalized or domain-specific phenomenon. Employing a well-va...
Coronary microvascular disease (CMD), particularly prevalent among women, is associated with increased morbidity and mortality, making clinical screening vital for effective management. However, limited publicly available screening-level data hinders...
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women that requires self-management to improve mental and physical health outcomes and reduce risk of comorbidity. Digital technology has rapidly emerged as a valuable self...
Recent advancements in cognitive neuroscience and digital technology have significantly accelerated the adoption of digital therapeutics for cognitive impairment. This viewpoint explores the innovative applications of digital therapeutics in the asse...
In the context of Evidence-Based Practice (EBP), Systematic Reviews (SRs), Meta-Analyses (MAs) and overview of reviews have become cornerstones for the synthesis of research findings. The Preferred Reporting Items for Systematic Reviews and Meta-Anal...
Lactylation, a novel post-translational modification, has been implicated in various pathophysiological processes; however, its role in sepsis-associated acute kidney injury (SA-AKI) remains unclear. This study aimed to investigate the expression pat...
Journal of cancer research and clinical oncology
Jun 12, 2025
PURPOSE: This study aimed to evaluate radiomic models' ability to predict hypoxia-related biomarker expression in clear cell renal cell carcinoma (ccRCC).
Image-guided minimally invasive ultrasound thermal ablation has been widely studied for disease treatment due to its unique advantages, such as large treatment volumes and conformal delivery of ablation energy. This review presents the state-of-the-a...
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