Alimentary pharmacology & therapeutics
Jun 5, 2025
BACKGROUND: Artificial intelligence (AI) has been applied extensively to eosinophilic oesophagitis (EoE), but its clinical impact and comprehensiveness remain unclear.
INTRODUCTION: The landscape of drug discovery is rapidly evolving, with natural products (NPs) playing a pivotal role in the development of novel therapeutics. Despite their historical significance, challenges persist in fully harnessing their potent...
British journal of hospital medicine (London, England : 2005)
Jun 5, 2025
Pulmonary embolism (PE) is a life-threatening condition with significant diagnostic challenges due to high rates of missed or delayed detection. Computed tomography pulmonary angiography (CTPA) is the current standard for diagnosing PE, however, dem...
Journal of chemical information and modeling
Jun 5, 2025
Synonymous mutations do not change amino acid sequences, but they can drive cancer by influencing splicing, mRNA structure, translation efficiency, and other molecular mechanisms. Although driver synonymous mutations are significantly outnumbered by ...
Journal of chemical information and modeling
Jun 5, 2025
The forecasting of drug-target interactions (DTIs) is a crucial element in the domain of drug repositioning. Current methodologies, primarily based on dual-branch architectures or graph neural networks (GNNs), typically model binary associations─spec...
Journal of chemical information and modeling
Jun 5, 2025
Small-molecule drugs play a critical role in cancer therapy by selectively targeting key signaling pathways that drive tumor growth. While deep learning models have advanced drug discovery, there remains a lack of generative frameworks for covalent ...
Journal of chemical information and modeling
Jun 5, 2025
Single-cell RNA sequencing (scRNA-seq) has become a crucial technology for analyzing cellular diversity at the single-cell level. Cell clustering is crucial in scRNA-seq data analysis as it accurately identifies distinct cell types and uncovers poten...
Journal of agricultural and food chemistry
Jun 5, 2025
The lack of suitable chemical research methodologies has hindered the discovery of rational daily diet combinations from large-scale dietary-derived compounds. Three deep learning models based on chemical properties for α-glucosidase inhibitors (AGIs...
BACKGROUND: Sedentary lifestyles can lead to musculoskeletal disorders, but proper sitting posture, particularly maintaining a slight anterior pelvic tilt, helps prevent issues like lower back pain and spinal misalignment. Samsung Electronics wearabl...
OBJECTIVE: The aim of this study was to automatically detect teeth with dens invaginatus (DI) in panoramic radiographs using deep learning algorithms and to compare the success of the algorithms.
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