AIMC Topic: Knowledge Bases
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KGDDS: A System for Drug-Drug Similarity Measure in Therapeutic Substitution based on Knowledge Graph Curation.
Journal of medical systems
Mar 5, 2019
Measuring drug-drug similarity is important but challenging. Significant progresses have been made in drugs whose labeled training data is sufficient and available. However, handling data skewness and incompleteness with domain-specific knowledge gra...
Automated Closed- and Open-Loop Validation of Knowledge-Based Planning Routines Across Multiple Disease Sites.
Practical radiation oncology
Mar 1, 2019
PURPOSE: Knowledge-based planning (KBP) clinical implementation necessitates significant upfront effort, even within a single disease site. The purpose of this study was to demonstrate an efficient method for clinicians to assess the noninferiority o...
Rare disease knowledge enrichment through a data-driven approach.
BMC medical informatics and decision making
Feb 14, 2019
BACKGROUND: Existing resources to assist the diagnosis of rare diseases are usually curated from the literature that can be limited for clinical use. It often takes substantial effort before the suspicion of a rare disease is even raised to utilize t...
[An online dynamic knowledge base in multiple languages on general medicine and primary care].
The Pan African medical journal
Feb 5, 2019
INTRODUCTION: The International Classification of Primary Care, Second version (ICPC-2) aligned with the 10th Revision of the International Classification of Disease (ICD-10) is a standard for primary care epidemiology compendium. ICPC-2 has been als...
Disease vocabulary size as a surrogate marker for physicians' disease knowledge volume.
PloS one
Dec 27, 2018
OBJECTIVE: Recognizing what physicians know and do not know about a particular disease is one of the keys to designing clinical decision support systems, since these systems can fulfill complementary role by recognizing this boundary. To our knowledg...
Knowledge-based dose prediction models for head and neck cancer are strongly affected by interorgan dependency and dataset inconsistency.
Medical physics
Dec 24, 2018
PURPOSE: The goal of this study was to generate a large treatment plan database for head and neck (H&N) cancer patients that can be considered as the gold standard to train and validate models for knowledge-based (KB) treatment planning and QA. With ...
Integrative Gene Selection on Gene Expression Data: Providing Biological Context to Traditional Approaches.
Journal of integrative bioinformatics
Dec 22, 2018
The advance of high-throughput RNA-Sequencing techniques enables researchers to analyze the complete gene activity in particular cells. From the insights of such analyses, researchers can identify disease-specific expression profiles, thus understand...
Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases: 2HADH knowledgebase.
BMC evolutionary biology
Dec 22, 2018
BACKGROUND: The family of D-isomer specific 2-hydroxyacid dehydrogenases (2HADHs) contains a wide range of oxidoreductases with various metabolic roles as well as biotechnological applications. Despite a vast amount of biochemical and structural data...
Converging a Knowledge-Based Scoring Function: DrugScore.
Journal of chemical information and modeling
Dec 18, 2018
We present DrugScore, a new version of the knowledge-based scoring function DrugScore, which builds upon the same formalism used to derive DrugScore but exploits a training data set of nearly 40 000 X-ray complex structures, a highly diverse and the,...
Multi-Institutional Validation of a Knowledge-Based Planning Model for Patients Enrolled in RTOG 0617: Implications for Plan Quality Controls in Cooperative Group Trials.
Practical radiation oncology
Dec 15, 2018
PURPOSE: This study aimed to evaluate the feasibility of using a single-institution, knowledge-based planning (KBP) model as a dosimetric plan quality control (QC) for multi-institutional clinical trials. The efficacy of this QC tool was retrospectiv...
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