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Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.

Cell
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will require better understanding of serotonergic circuitry, which ha...

Machine learning-based e-commerce platform repurchase customer prediction model.

PloS one
In recent years, China's e-commerce industry has developed at a high speed, and the scale of various industries has continued to expand. Service-oriented enterprises such as e-commerce transactions and information technology came into being. This pap...

Machine learning predicts live-birth occurrence before in-vitro fertilization treatment.

Scientific reports
In-vitro fertilization (IVF) is a popular method of resolving complications such as endometriosis, poor egg quality, a genetic disease of mother or father, problems with ovulation, antibody problems that harm sperm or eggs, the inability of sperm to ...

Identification of contributing genes of Huntington's disease by machine learning.

BMC medical genomics
BACKGROUND: Huntington's disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is s...

Evaluation of incomplete maternal smoking data using machine learning algorithms: a study from the Medical Birth Registry of Norway.

BMC pregnancy and childbirth
BACKGROUND: The Medical Birth Registry of Norway (MBRN) provides national coverage of all births. While retrieval of most of the information in the birth records is mandatory, mothers may refrain to provide information on her smoking status. The prop...

Using Auto-Segmentation to Reduce Contouring and Dose Inconsistency in Clinical Trials: The Simulated Impact on RTOG 0617.

International journal of radiation oncology, biology, physics
PURPOSE: Contouring inconsistencies are known but understudied in clinical radiation therapy trials. We applied auto-contouring to the Radiation Therapy Oncology Group (RTOG) 0617 dose escalation trial data. We hypothesized that the trial heart doses...

Age estimation based on 3D pulp chamber segmentation of first molars from cone-beam-computed tomography by integrated deep learning and level set.

International journal of legal medicine
OBJECTIVES: To develop an automatic segmentation method to segment the pulp chamber of first molars from 3D cone-beam-computed tomography (CBCT) images, and to estimate ages by calculated pulp volumes.

Self-Optimizing Support Vector Elastic Net.

Analytical chemistry
Chemometrics is widely used to solve various quantitative and qualitative problems in analytical chemistry. A self-optimizing chemometrics method facilitates scientists to exploit the advantages of chemometrics. In this report, a parameter-free suppo...

Prediction of power generation and rotor angular speed of a small wind turbine equipped to a controllable duct using artificial neural network and multiple linear regression.

Environmental research
Wind power is one of the most popular sources of renewable energies with an ideal extractable value that is limited to 0.593 known as the Betz-Joukowsky limit. As the generated power of wind machines is proportional to cubic wind speed, therefore it ...

Artificial intelligence automates and augments baseline impedance measurements from pH-impedance studies in gastroesophageal reflux disease.

Journal of gastroenterology
BACKGROUND: Artificial intelligence (AI) has potential to streamline interpretation of pH-impedance studies. In this exploratory observational cohort study, we determined feasibility of automated AI extraction of baseline impedance (AIBI) and evaluat...